Anti-Fibroblast growth factor 19 FGF19 Antibody
Rabbit IgG polyclonal antibody for Fibroblast growth factor 19(FGF19) detection. Tested with WB, IHC-P in Human.
Anti-Fibroblast growth factor 19 FGF19 Antibody Info At A Glance
|Product Name||Anti-Fibroblast growth factor 19 FGF19 Antibody
See all FGF-19 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for FGF-19/FGF19 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. FGF-19/FGF19 information: Molecular Weight: 24003 MW; Subcellular Localization: Secreted; Tissue Specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder.|
|Cite This Product||Anti-Fibroblast growth factor 19 FGF19 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1476)|
|Similar Products From
|Anti-Fibroblast growth factor 19 FGF19 Antibody may replace the following items: sc 59393|sc 19441|sc 292644|sc 393710|sc 398238.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human FGF19(124-140aa EEIRPDGYNVYRSEKHR).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For FGF19 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||9965|
|Species Of This Entry||Human|
|Protein Name||Fibroblast growth factor 19|
|Superfamily||heparin-binding growth factors family|
|Alternative Names||FGF-19|FGF19; FGF-19; fibroblast growth factor 19|
|Post Tranlational Modifications||Phosphorylation; Glycosylation; Cleavage; Oxidation; Ubiquitination; Methylation|
|Gene Location||11q13.3, on Chromasome 11, gene sequence: NC_000011.10 (69698238..69704022, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For FGF19 (Source: Uniprot.org, NCBI)
|Protein Function||Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.|
|Tissue Specificity||Expressed in fetal brain, cartilage, retina, and adult gall bladder.|
|Related Diseases||Neoplasms; Malignant Neoplasms; Carcinoma; Diabetes Mellitus; Liver Carcinoma; Obesity; Diarrhea; Malabsorption Syndrome; Diabetes Mellitus, Non-insulin-dependent; Chronic Diarrhea; Insulin Resistance; Liver Neoplasms; Insulin Sensitivity; Malignant Tumor Of Colon; Malignant Squamous Cell Neoplasm; Irritable Bowel Syndrome; Atherosclerosis; Carcinogenesis; Metabolic Diseases|
|Related Pathways||Cell Proliferation; Pathogenesis; Transport; Secretion; Glucose Homeostasis; Lipid Homeostasis; Energy Homeostasis; Localization; Gluconeogenesis; Hepatocyte Proliferation; Cell Growth; Eye Development; Regulation Of Glucose Homeostasis; Excretion; Aging; Angiogenesis; Cell Adhesion; Cell Migration; Glycosylation; Neurogenesis|
|Background||FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this gene is a member of the fibroblast growth factor(FGF) family. The FGF19 gene is mapped to 11q13.3. The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity.|
|Scientific References||PMID: 9931477 by Nishimura T., et al. Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain.|
PMID: 10525310 by Xie M.-H., et al. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
Our Boster Quality Guarantee for Anti-Fibroblast growth factor 19 FGF19 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti FGF19 (PA1476) at 0.5ug/ml
Lane 1: U87 Whole Cell Lysate at 40ug
Lane 2: SMMC Whole Cell Lysate at 40ug
Predicted bind size: 24KD
Observed bind size: 24KD
IHC(P): Human Gallbladder Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
Other Recommended Resources
Here are featured tools and databases that you might find useful.
Order Product (PA1476)
Domestically in USA and Canada, ships next business day if available in stock.
Note: sample size takes longer to process, average 5-7 days.
All Boster antibodies and ELISA kits are guaranteed to meet the specifications on the data sheet.See Details
Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.Download Free PDFs Now
Guaranteed product quality
We promise all of our products perform as described in datasheets.