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Product Info Summary
|Reactive Species:||Human, Mouse, Rat|
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Anti-HDAC-2 (C-terminus) Antibody
Boster Bio Anti-HDAC-2 (C-terminus) Antibody catalog # A00325. Tested in IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Cite This Product
Anti-HDAC-2 (C-terminus) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00325)
No cross reactivity with other proteins.
A00325 is reactive to HDAC2 in Human, Mouse, Rat
A00325 is guaranteed for IF Boster Guarantee
Background of Histone Deacetylase 2/HDAC2
Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene. This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Betz et al. (1998) performed PCR using HDAC2-specific primers to screen a somatic cell hybrid mapping panel. They mapped the HDAC2 gene to human chromosome 6q21, a region of the genome altered in some cancers, including retinoblastoma.
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
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Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
Western Blot, 1μg/ml, human, mouse, rat, Primate
Direct ELISA, 1:20, 000 - 1:60, 000, human, mouse, rat, Primate
Immunohistochemistry: 1:100-1:500, human, mouse, rat, Primate
IF Microscopy: 1:100-1:500, human, mouse, rat, Primate
Validation Images & Assay Conditions
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Western blot analysis of HDAC2 expression in mouse brain extract (lane 1) and mouse brain extract blocked with peptide (lane 2). HDAC2 at 59KD was detected using rabbit anti-HDAC-2 Antigen Affinity purified polyclonal antibody (Catalog # A00325) at 1 μg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).
Gene/Protein Information For HDAC2 (Source: Uniprot.org, NCBI)
Histone deacetylase 2
histone deacetylase family
EC 126.96.36.199; HD2; HDAC2; Histone Deacetylase 2; RPD3; transcriptional regulator homolog RPD3; YAF1; YY1-associated factor 1 HDAC2 HD2, KDAC2, RPD3, YAF1 histone deacetylase 2 histone deacetylase 2|YY1-associated factor 1|transcriptional regulator homolog RPD3*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".
For more info on HDAC2, check out the HDAC2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HDAC2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]
A00325 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Chen Xm, Xie Xb, Zhao Q, Wang F, Bai Y, Yin Jq, Jiang H, Xie Xl, Jia Q, Huang G. Mol Med Rep. 2015 Jan;11(1):105-12. Doi: 10.3892/Mmr.2014.2733. Epub 2014 Oct 21. Ampelopsin Induces Apoptosis By Regulating Multiple C-Myc/S-Phase Kinase-Associated ...
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