Anti-Histone deacetylase 2 HDAC2 Antibody
Rabbit IgG polyclonal antibody for Histone deacetylase 2(HDAC2) detection. Tested with WB in Human;Mouse;Rat. Cited in 2 publication(s).
Anti-Histone deacetylase 2 HDAC2 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Histone deacetylase 2 HDAC2 Antibody
See all Histone Deacetylase 2/HDAC2 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Histone Deacetylase 2/HDAC2 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Histone Deacetylase 2/HDAC2 information: Molecular Weight: 55364 MW; Subcellular Localization: Nucleus . Cytoplasm ; Tissue Specificity: Widely expressed; lower levels in brain and lung.|
|Cite This Product||Anti-Histone deacetylase 2 HDAC2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1350)|
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|Anti-Histone deacetylase 2 HDAC2 Antibody may replace the following items: sc 56685|sc 7899|sc 55542|sc 9959|sc 6296|sc 55541|sc 81599|sc 6296 R|sc 7899 X|sc 6296 X.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human HDAC2(464-478aa EDKSKDNSGEKTDTK), identical to the related rat sequence, and different from the related mouse sequence by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For HDAC2 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||3066|
|Species Of This Entry||Human|
|Protein Name||Histone deacetylase 2|
|Superfamily||histone deacetylase family|
|Alternative Names||Histone Deacetylase 2/HDAC2|EC 220.127.116.11; HD2; HDAC2; Histone Deacetylase 2; RPD3; transcriptional regulator homolog RPD3; YAF1; YY1-associated factor 1|
|Post Tranlational Modifications||Acetylation; Deacetylation; Methylation; Phosphorylation; Nitrosylation; Demethylation; Sumoylation; Ubiquitination; Cleavage; Nitration; Reduction; Dephosphorylation; Phosphorothioation; Citrullination; Ribosylation|
|Subcellular Localization||Nucleus. Cytoplasm.|
|Gene Location||6q21, on Chromasome 6, gene sequence: NC_000006.12 (113933028..113971148, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For HDAC2 (Source: Uniprot.org, NCBI)
|Protein Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.|
|Tissue Specificity||Widely expressed; lower levels in brain and lung.|
|Interacting Proteins||BCL11B; BRMS1; DAXX; HCFC1; HDAC1; MBD1; MTA1; MYC; NPM1; RFX5; SIN3A; SNAI1; SRA1; SUV39H1; ZNF827|
|Research Areas||Breast Cancer; Cancer; Chromatin Research; Epigenetics; Phospho-Specific; Stem Cell Markers|
|Related Diseases||Malignant Neoplasms; Neoplasms; Inflammation; Traditional Serrated Adenoma; Chronic Obstructive Airway Disease; Lung Diseases; Lung Diseases, Obstructive; Carcinoma; Asthma; Malignant Neoplasm Of Breast; Leukemia; Mammary Neoplasms; Cell Transformation, Neoplastic; Malignant Tumor Of Colon; Neoplasm Metastasis; Malignant Paraganglionic Neoplasm; Retinoblastoma; Colorectal Cancer; Malignant Neoplasm Of Prostate|
|Related Pathways||Histone Acetylation; Cell Cycle; Methylation; Chromatin Remodeling; Histone Deacetylation; Cell Proliferation; Dna Methylation; Pathogenesis; Localization; Cell Growth; Cell Differentiation; Regulation Of Gene Expression; Cell Cycle Arrest; Histone Modification; Gene Silencing; Histone H3 Acetylation; Cell Death; Secretion; Inflammatory Response; Rna Interference|
|Background||Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene. This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones(H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Betz et al.(1998) performed PCR using HDAC2-specific primers to screen a somatic cell hybrid mapping panel. They mapped the HDAC2 gene to human chromosome 6q21, a region of the genome altered in some cancers, including retinoblastoma.|
|Scientific References||PMID: 8917507 by Yang W.-M., et al. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.|
PMID: 10545197 by Schmidt D.R., et al. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.
Our Boster Quality Guarantee for Anti-Histone deacetylase 2 HDAC2 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: MM453 Cell Lysate
Lane 2: MCF-7 Cell Lysate
Lane 3: HELA Cell Lysate
Lane 4: SMMC Cell Lysate
Lane 5: COLO320 Cell Lysate
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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Total number of citations: 2
|Chen Xm, Bai Y, Zhong Yj, Xie Xl, Long Hw, Yang Yy, Wu Sg, Jia Q, Wang Xh. Plos One. 2013 Nov 12;8(11):E79201. Doi: 10.1371/Journal.Pone.0079201. Ecollection 2013. Wogonin Has Multiple Anti-Cancer Effects By Regulating C-Myc/Skp2/Fbw7?? And Hdac1/...||PubMed ID 24265759|
|Chen Xm, Xie Xb, Zhao Q, Wang F, Bai Y, Yin Jq, Jiang H, Xie Xl, Jia Q, Huang G. Mol Med Rep. 2015 Jan;11(1):105-12. Doi: 10.3892/Mmr.2014.2733. Epub 2014 Oct 21. Ampelopsin Induces Apoptosis By Regulating Multiple C-Myc/S-Phase Kinase-Associated ...||PubMed ID 25333250|
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