Anti-KV1.5 KCNA5 Antibody

Product Name

Anti-KV1.5 KCNA5 Antibody

View all Kv1.5 Antibodies

SKU/Catalog Number

A02673

Size

100μl

Form

Liquid

Description

Boster Bio Anti-KV1.5 KCNA5 Antibody catalog # A02673. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-KV1.5 KCNA5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02673)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

5H2

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human KV1.5. at AA rangle: 230-310

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02673 is reactive to KCNA5 in Human, Mouse, Rat

Applications

A02673 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

67.228kDa

Background of Kv1.5

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Kanai F., Marignani P.A., Sarbassova D., Yagi R. EMBO J. 19:6778-6791(2000)
Lei Q.Y., Zhang H., Zhao B., Zha Z.Y. Mol. Cell. Biol. 28:2426-2436(2008)
Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R. Nat. Cell Biol. 10:837-848(2008)
Di Palma T., D'Andrea B., Liguori G.L., Liguoro A. Exp. Cell Res. 315:162-175(2009)

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis of specific cells using KV1.5 Polyclonal antibody.

Gene/Protein Information For KCNA5 (Source: Uniprot.org, NCBI)

Alternative Names

HK2; insulinoma and islet potassium channel; PCN1; potassium channel 1; potassium voltage-gated channel, shaker-related subfamily, member 5; voltage-gated potassium channel HK2 KCNA5 ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1 potassium voltage-gated channel subfamily A member 5 potassium voltage-gated channel subfamily A member 5|cardiac potassium channel|insulinoma and islet potassium channel|potassium channel 1|potassium channel, voltage gated shaker related subfamily A, member 5|potassium voltage-gated channel, shaker-related subfamily, member 5|voltage-gated potassium channel HK2|voltage-gated potassium channel protein Kv1.5|voltage-gated potassium channel subunit Kv1.5

For more info on KCNA5, check out the KCNA5 Infographic

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In this infographic, you will see the following information for KCNA5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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