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- Table of Contents
239 Citations 1 Q&As
72 Citations 4 Q&As
2 Citations 1 Q&As
Facts about Actin, aortic smooth muscle.
Human | |
---|---|
Gene Name: | ACTA2 |
Uniprot: | P62736 |
Entrez: | 59 |
Belongs to: |
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actin family |
1a4 sma; 1a4 smooth muscle actin; AAT6; ACTA2; Actin alpha 2; actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha sma 1a4; alpha SMA; alpha smooth muscle actin; alpha-actin-2; alpha-SMA; alphaSmooth Muscle Actin; alpha-Smooth Muscle Actin; a-sma; Cell growth-inhibiting gene 46 protein; growth-inhibiting gene 46; MYMY5; sma 1a4; SMA; smooth muscle actin
Mass (kDA):
42.009 kDA
Human | |
---|---|
Location: | 10q23.31 |
Sequence: | 10; NC_000010.11 (88935074..88991397, complement) |
Cytoplasm, cytoskeleton.
If you're trying to figure out how to use the Boster Bio Antibody, you've come to the right place. In this article, we'll explore the different uses for this antibody, including IF, ICC, and WB. In addition, we'll go over Detection and Sensitivity. Finally, we'll cover the Boster Bio's catalog number, A01072-1.
The ACTA2 antibody by Boster Bio is a monoclonal anti-actin antibody that has been validated for use in immunohistochemistry, IHC, and WB. It reacts with Human and Mouse, as well as Rat. These applications make it an excellent choice for a variety of immunological procedures. Listed below are some of the Best Uses Of The ACTA2 marker in Boster Bio.
The ACTA2 gene is expressed in primary neural stem cells (NSCs), and downregulation of the ACTA2 gene inhibits NSC migration and actin filament polymerization. The downregulation of ACTA2 is interesting because it adds to the basic knowledge of NSC migration and provides a target for improving the potential of NSCs to migrate after CNS injury. The current data also show that downregulation of ACTA2 may aid functional recovery after CNS injury.
The ACTA2 gene has high specificity for alveolar MYF and SMC lineages. In a study of mice, tamoxfien injection at E15.5 resulted in 91 + 5% labeling of alveolar MYFs. The expression of ACTA2 has also been linked to the occurrence of early and late differentiated MYFs in lung tissue.
This gene encodes the a-actin protein, which is a critical component of vascular smooth muscle cells. Pathogenic variants of ACTA2 are the most common genetic cause of HTAD. Although thoracic aortic aneurysm is the most common clinical manifestation of ACTA2-related vasculopathy, extravascular manifestations are also common. The present data also suggest that mutation-specific vascular traits may exist.
Using all genes to cluster cells is a more precise method for detecting heterogeneous cell populations. While canonical cell-type specific markers are more sensitive, using all genes to differentiate between subpopulations of SMCs is more efficient. Therefore, we believe that ACTA2-deficient mice may have a higher degree of heterogeneity in the human body. These findings are of great interest to cancer researchers.
Several studies have shown a relationship between ACTA2 gene expression and drug sensitivity. TdTomato+ cells are present at E15.5, but show limited expansion and limited proliferation. ACTA2 is a marker of differentiated SMCs, but has also been described for differentiated alveolar MYF. As a result, a low ACTA2 value in lung tissue may be associated with early or late differentiation.
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PMID: 2701935 by Kamada S., et al. The nucleotide sequence of a human smooth muscle alpha-actin (aortic type) cDNA.
PMID: 2295650 by Reddy S., et al. Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region.
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page