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- Table of Contents
G1/S-specific cyclin-D1 Antibodies
AND CCND1 ELISA kits, G1/S-specific cyclin-D1 Proteins
Many biological assays use antibodies to detect G1/S-specific cyclin-D1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with G1/S-specific cyclin-D1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop G1/S-specific cyclin-D1 antibodies...
Designing a Western blot for G1/S-specific cyclin-D1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CCND1 Western Blot GuideCCND1 Infographic by Boster Bio
All CCND1 Products
Product
Figures
Specificity
Applications
Price
Anti-Cyclin D1/CCND1 Antibody Picoband®
71 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # PB9370
100 μg/vial
Cat # PB9370
100 μg/vial
Anti-Cyclin D1 CCND1 Rabbit Monoclonal Antibody
25 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00149-1
100 μl
Cat # M00149-1
100 μl
Anti-Cyclin D1/CCND1 Antibody Picoband®
37 Citations
Human, Mouse, Rat
WB
$370
Cat # PA1245-1
100 μg/vial
Cat # PA1245-1
100 μg/vial
Human
IHC, WB
$449
Cat # M00149-3
100ul
Cat # M00149-3
100ul
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00149-5
20μL, 40μL, 100μL, 200μL
Cat # M00149-5
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00149T286-1
100ul
Cat # A00149T286-1
100ul
Human, Mouse, Rat
ELISA
$540
Cat # EKC2024
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2024
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1153
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1153
1 kit, containing one 96-well plate and all necessary reagents
CCND1 Overview
Facts about G1/S-specific cyclin-D1.
G1/S-specific cyclin-D1 (CCND1)
Regulatory part of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the following transcription of E2F target genes that are responsible for the progression through the G(1) phase.
Cyclin D-CDK4 complexes are important integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCND1 |
| Uniprot: | P24385 |
| Entrez: | 595 |
Family
| Belongs to: |
|---|
| cyclin family |
Alternative Names
B-cell lymphoma 1 protein; BCL-1 oncogene; Bcl-1; BCL1D11S287E; CCND1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); Cyclin D1; Cyl-1; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; PRAD1; PRAD1B-cell CLL/lymphoma 1; U21B31
Molecular Weight
Mass (kDA):
33.729 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.3 |
| Sequence: | 11; NC_000011.10 (69641156..69654474) |
Subcellular Localizations
Nucleus. Cytoplasm. Nucleus membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Lymphoma
- Malignant Squamous Cell Neoplasm
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse
- Carcinogenesis
- Neoplasm Metastasis
Interacting Proteins
- AR
- BRCA1
- CDC27
- CDK2
- CDK4
- Cdk4
- CDK6
- CDKN1A
- CDKN1B
- FBXO31
Pathways
- Cell Cycle
- Cell Proliferation
- Cell Growth
- Pathogenesis
- S Phase
- Cell Cycle Arrest
- Localization
- Interphase
- G1 Phase
- Methylation
- Cell Death
- Translation
- Reverse Transcription
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
- Ubiquitination
- Demethylation
- Dephosphorylation
- Deacetylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Core ESC-Like Genes
- mTOR Pathway
- Stem Cell Markers
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCND1
bosterbio.com/bosterbio-gene-info-cards/CCND1
References
PMID: 1826542 by Motokura T., et al. A novel cyclin encoded by a bcl1-linked candidate oncogene.
PMID: 1833066 by Lew D.J., et al. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.
50 Publications of Boster G1/S-specific cyclin-D1 Antibodies & ELISA Kits
- PubMed ID: 31467112, Chen Q, Deng X,Hu X,Guan S,He M,Wang Y,Wei B,Zhang J,Zhao H,Yao W,Jin F,Liu Y,Ch...
- PubMed ID: 30610869, Xiang W,Jiang T,Hao X, Wang R,Yao X,Sun K,Guo F,Xu T.Primary cilia and autophagy...
- PubMed ID: 31102746, Zhang H,Su Y,Wang J,Gao Y,Yang F,Li G,Shi Q.Ginsenoside Rb1 promotes the growth ...
- PubMed ID: 33289736, Liu S,Sun Y,Zhao R,Wang Y,Zhang W,Pang W. Isoleucine increases muscle mass throu...
- PubMed ID: 33066831, Nan W,Li G,Si H,Lou Y,Wang D,Guo R,Zhang H.All-trans-retinoic acid inhibits mink...
- PubMed ID: 31974617, Wang S,Zhang C,Zhang X.Downregulation of long non‑coding RNA ANRIL promotes pr...
- PubMed ID: 33292254, Wang C,Shao S,Deng L,Wang S,Zhang Y. LncRNA SNHG12 regulates the radiosensitivit...
- PubMed ID: 31259714, The antitumor activity of umbelliferone in human renal cell carcinoma via regula...
- PubMed ID: 30867962, Effects of Buddleja officinalis granules on apoptosis factors Bax, Caspase-3, Fa...
- PubMed ID: 24829131, Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes
- PubMed ID: 30283340, Overexpression of MYCT1 inhibits proliferation and induces apoptosis in human ac...
- PubMed ID: 28944904, Triptolide inhibits proliferation, differentiation and induces apoptosis of oste...
- PubMed ID: 30015847, LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cell...
- PubMed ID: 29674607, Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apop...
- PubMed ID: 29436690, Effects of low-intensity ultrasound combined with low-dose carboplatin in an ort...
- PubMed ID: 27602489, Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via e...
- PubMed ID: 27203545, Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 a...
- PubMed ID: 26902620, Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuati...
- PubMed ID: 26885058, The expression of AEG-1 and Cyclin D1 in human bladder urothelial carcinoma and ...
- PubMed ID: 26837415, Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migrati...
- PubMed ID: 26526388, CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell rec...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page