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CDKN1B Antibodies
AND CDKN1B ELISA kits, CDKN1B Proteins
Many biological assays use antibodies to detect CDKN1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDKN1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDKN1B antibodies...
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CDKN1B Infographic by Boster Bio
All CDKN1B Products
Product
Figures
Specificity
Applications
Price
Anti-p27Kip1 CDKN1B Antibody (Monoclonal, DCS-72)
1 Citations 7 Q&As
Human, Mouse, Rat
ICC, WB
$370
Cat # MA1076
100 μg/vial
Cat # MA1076
100 μg/vial
Anti-p27 KIP 1/CDKN1B Antibody Picoband®
9 Citations 2 Q&As
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # PB9070
100 μg/vial
Cat # PB9070
100 μg/vial
Anti-p27 KIP 1 CDKN1B Rabbit Monoclonal Antibody
1 Citations 1 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00173-1
100 μl
Cat # M00173-1
100 μl
Human
IHC, WB
$449
Cat # M00173-2
100uL
Cat # M00173-2
100uL
Human
ELISA
$480
Cat # EKC1419
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1419
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2266
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2266
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2482
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2482
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2483
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2483
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00173T187-1
100ul
Cat # A00173T187-1
100ul
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00173-3
20μL, 40μL, 100μL, 200μL
Cat # M00173-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P00173-1
100 μl/vial
Cat # P00173-1
100 μl/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P00173-2
100 μl/vial
Cat # P00173-2
100 μl/vial
CDKN1B Overview
Facts about Cyclin-dependent kinase inhibitor 1B.
Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory action on CDK2 bound to SPDYA (PubMed:28666995).
Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A- CDK2 complexes.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDKN1B |
| Uniprot: | P46527 |
| Entrez: | 1027 |
Family
| Belongs to: |
|---|
| CDI family |
Alternative Names
CDKN1B; CDKN4; cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; Kip1; KIP1P27KIP1; MEN1B; MEN4; p27; p27Kip1
Molecular Weight
Mass (kDA):
22.073 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.1 |
| Sequence: | 12; NC_000012.12 (12717368..12722369) |
Tissue Specificity
Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Subcellular Localizations
Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity).
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Retinoblastoma
- Cell Transformation, Neoplastic
- Hyperplasia
- Growth Arrest
- Malignant Paraganglionic Neoplasm
- Leukemia
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Prostatic Neoplasms
Interacting Proteins
- Abl1
- CCNA1
- CCNA2
- CCNB1
- CCND1
- CCND2
- CCNE1
- CCNE2
- CDK2
- CDK4
Pathways
- Cell Cycle
- Cell Proliferation
- Cell Cycle Arrest
- S Phase
- Cell Growth
- G1 Phase
- Localization
- Cell Death
- Pathogenesis
- Cell Differentiation
- Senescence
- Cell Division
- Proteolysis
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
- Methylation
- Dephosphorylation
- Acetylation
- Reduction
- Phosphorothioation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDKN1B
bosterbio.com/bosterbio-gene-info-cards/CDKN1B
References
PMID: 8033212 by Polyak K., et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
PMID: 7882309 by Pietenpol J.A., et al. Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.
2 Publications of Boster CDKN1B Antibodies & ELISA Kits
- PubMed ID: 21575146, Hepatitis B virus induces G1 phase arrest by regulating cell cycle genes in HepG...
- PubMed ID: 22108090, Li Bh, Xu Sb, Li F, Zou Xg, Saimaiti A, Simayi D, Wang Yh, Zhang Y, Yuan J, Zhan...
*More publications can be found for each product on its corresponding product page