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CDKN2B Antibodies
AND CDKN2B ELISA kits, CDKN2B Proteins
Many biological assays use antibodies to detect CDKN2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDKN2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDKN2B antibodies...
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CDKN2B Infographic by Boster Bio
All CDKN2B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$523
Cat # M01500
100 µl
Cat # M01500
100 µl
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M01500-1
100 µl
Cat # M01500-1
100 µl
CDKN2B Overview
Facts about Cyclin-dependent kinase 4 inhibitor B.
Cyclin-dependent kinase 4 inhibitor B (CDKN2B)
Interacts strongly with CDK4 and CDK6.
Potent inhibitor.Possible effector of TGF-beta induced cell cycle arrest. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CDKN2B |
| Uniprot: | P42772 |
| Entrez: | 1030 |
Family
| Belongs to: |
|---|
| CDKN2 cyclin-dependent kinase inhibitor family |
Alternative Names
CDK4I; CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; INK4BCDK4B inhibitor; MTS2; MTS-2; MTS2CDK inhibitory protein; Multiple tumor suppressor 2; p14_CDK inhibitor; p14_INK4B; p14-INK4b; p15 CDK inhibitor; p15_INK4B; P15cyclin-dependent kinase 4 inhibitor B; p15INK4b; p15-INK4b; TP15
Molecular Weight
Mass (kDA):
14.722 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p21.3 |
| Sequence: | 9; NC_000009.12 (22002903..22009313, complement) |
Tissue Specificity
Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.
Subcellular Localizations
Cytoplasm. Also found in the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Leukemia
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Acute Lymphocytic Leukemia
- Myeloid Leukemia
- Retinoblastoma
- Leukemia, Myelocytic, Acute
- Lymphoma
- Diabetes Mellitus
- Melanoma
Interacting Proteins
- CDK4
- CDK6
- MAGEA11
- NIF3L1
- SPG21
- TRAF1
Pathways
- Methylation
- Cell Cycle
- Pathogenesis
- Cell Proliferation
- Dna Methylation
- Cell Growth
- G1 Phase
- Cell Cycle Arrest
- Senescence
- Gene Silencing
- S Phase
- Demethylation
- Secretion
PTMs
- Methylation
- Phosphorylation
- Demethylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDKN2B
bosterbio.com/bosterbio-gene-info-cards/CDKN2B
References
PMID: 8001816 by Guan K.-L., et al. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
PMID: 8078588 by Hannon G.J., et al. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.