Estrogen receptor (ESR1)

Nuclear hormone receptor. Ligand-dependent atomic transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling.

Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their various components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type particular manner.