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- Table of Contents
HMGB1 Antibodies
AND HMGB1 ELISA kits, HMGB1 Proteins
Many biological assays use antibodies to detect HMGB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HMGB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HMGB1 antibodies...
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HMGB1 Infographic by Boster Bio
All HMGB1 Products
Product
Figures
Specificity
Applications
Price
Anti-HMGB1 Antibody Picoband®
23 Citations 17 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00066-1
100 μg/vial
Cat # A00066-1
100 μg/vial
Anti-HMGB1/Hmg 1 Rabbit Monoclonal Antibody
9 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00066-1
100 μl
Cat # M00066-1
100 μl
Anti-HMGB1 Antibody Picoband® (monoclonal, 5H3)
1 Citations 5 Q&As
Human, Monkey, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M00066-2
100 μg/vial
Cat # M00066-2
100 μg/vial
Human
Cell Culture
$77
Cat # PROTP09429-3
5ug,20ug,100ug
Cat # PROTP09429-3
5ug,20ug,100ug
Human
Cell Culture
$77
Cat # PROTP09429-4
5ug,20ug,100ug
Cat # PROTP09429-4
5ug,20ug,100ug
Human
Cell Culture
$77
Cat # PROTP09429-5
5ug,20ug,100ug
Cat # PROTP09429-5
5ug,20ug,100ug
Human
Cell Culture
$77
Cat # PROTP09429-6
5ug,20ug,100ug
Cat # PROTP09429-6
5ug,20ug,100ug
Mouse
Cell Culture
$77
Cat # PROTP63158
5ug,20ug,100ug
Cat # PROTP63158
5ug,20ug,100ug
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00066-6
20μL, 40μL, 100μL, 200μL
Cat # M00066-6
20μL, 40μL, 100μL, 200μL
HMGB1 Overview
Facts about High mobility group protein B1.
High mobility group protein B1 (HMGB1)
Multifunctional redox sensitive protein with various roles in different cellular compartments. From the nucleus is one of the major chromatin-associated non-histone proteins and functions as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability.
Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is included in the coordination and integration of both innate and adaptive immune responses.
Gene Information
| Human | |
|---|---|
| Gene Name: | HMGB1 |
| Uniprot: | P09429 |
| Entrez: | 3146 |
Family
| Belongs to: |
|---|
| HMGB family |
Alternative Names
Amphoterin; high mobility group box 1; High mobility group protein 1; high mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; HMG1; HMG-1; HMG1DKFZp686A04236; HMG3; HMGB1; SBP-1; Sulfoglucuronyl carbohydrate binding protein
Molecular Weight
Mass (kDA):
24.894 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q12.3 |
| Sequence: | 13; NC_000013.11 (30456704..30617597, complement) |
Tissue Specificity
Ubiquituous. Expressed in platelets (PubMed:11154118).
Subcellular Localizations
Nucleus. Chromosome. Cytoplasm. Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Endosome. Endoplasmic reticulum-Golgi intermediate compartment. In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving
Diseases
- Inflammation
- Systemic Infection
- Neoplasms
- Malignant Neoplasms
- Inflammatory Response
- Ischemia
- Lung Injury
- Reperfusion Injury
- Arthritis
- Acute Lung Injury
- Infarction
- Tissue Adhesions
- Carcinoma
Interacting Proteins
- AGER
- AGTRAP
- BECN1
- HTT
- MSH2
- TP53
Pathways
- Pathogenesis
- Secretion
- Inflammatory Response
- Cell Death
- Immune Response
- Localization
- Autophagy
- Cell Proliferation
- Cytokine Production
- Cell Migration
- Angiogenesis
- Cell Activation
- Regeneration
PTMs
- Phosphorylation
- Cleavage
- Acetylation
- Oxidation
- Reduction
- Methylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMGB1
bosterbio.com/bosterbio-gene-info-cards/HMGB1
References
PMID: 2922262 by Wen L., et al. A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.
PMID: 8661151 by Ferrari S., et al. The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13.
14 Publications of Boster HMGB1 Antibodies & ELISA Kits
- PubMed ID: 10.5812/hepatmon.23552, Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcino...
- PubMed ID: 10.1136/jitc-2020-001966, Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling...
- PubMed ID: 10.1111/cas.14813, HMGB1 is a key factor for tamoxifen resistance and has the potential to predict ...
- PubMed ID: 10.1097/FJC.0000000000000353, Effects of Ethyl Pyruvate in Preventing the Development of Diet-induced Atherosc...
- PubMed ID: 10.1016/j.phymed.2014.10.011, Total extract of Yupingfeng attenuates bleomycin-induced pulmonary fibrosis in r...
- PubMed ID: 33712445, Hubert P,Roncarati P, Demoulin S, Pilard C, Ancion M, Reynders C, Lerho T, Bruye...
- PubMed ID: 32417325, Wang F,Ji S,Wang M,Liu L,Li Q,Jiang F,Cen J,Ji B.HMGB1 promoted P-glycoprotein a...
- PubMed ID: 31933513, Wen Y,Sun HY,Tan Z,Liu RH,Huang SQ,Chen GY,Qi H,Tang LJ.Abdominal paracentesis d...
- PubMed ID: 29497773, MicroRNA-205%u20115b inhibits HMGB1 expression in LPS-induced sepsis
- PubMed ID: 29073894, Propofol inhibits the release of interleukin-6, 8 and tumor necrosis factor-? co...
- PubMed ID: 26648090, Galantamine protects against lipopolysaccharide-induced acute lung injury in rat...
- PubMed ID: 26571038, The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is ...
- PubMed ID: 25685165, Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcino...
- PubMed ID: 28962112, Yang B, Gao P, Wu X, Yu J, Li Y, Meng R, Li Y, Yan J, Jin X. Exp Ther Med. 2017 ...
*More publications can be found for each product on its corresponding product page