IGF1 Antibodies

Insulin-like growth factor I (IGF1)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting action. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts.

Stimulates glucose transfer in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only seeing glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240).

Gene Information

Human
Gene Name:	IGF1
Uniprot:	P05019
Entrez:	3479

Family

Belongs to:
insulin family

Alternative Names

IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C

Molecular Weight

Mass (kDA):
21.841 kDA

Genomic Context

Human
Location:	12q23.2
Sequence:	12; NC_000012.12 (102395860..102481839, complement)

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Diabetes Mellitus
• Insulin Resistance
• Acromegaly
• Pituitary Diseases
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Obesity
• Dwarfism
• Growth Retardation
• Hypertrophy
• Diabetes Mellitus, Non-insulin-dependent

• Carcinoma
• Growth Disorders
• Somatotropin Deficiency
• Insulin Sensitivity
• Adenoma
• Hyperplasia
• Fetal Growth Retardation

Interacting Proteins

• IGF1R
• IGFBP1
• IGFBP4
• INSR

Pathways

• Secretion
• Cell Proliferation
• Aging
• Cell Cycle
• Cell Growth
• Pathogenesis
• Regeneration
• Transport
• Localization
• Angiogenesis
• Cell Death
• Ovulation
• Insulin Secretion

• Glucose Homeostasis
• Lactation
• Translation
• Cell Differentiation
• Reverse Transcription
• Immune Response
• Hormone Secretion

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Acetylation
• Iodination
• Oxidation
• Dephosphorylation

• Ubiquitination
• Glycosylation
• Demethylation
• Acylation
• Ribosylation
• Biotinylation
• Nitration

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IGF1

Best Uses Of The IGF1 Marker

IGF-1 is an growth hormone that stimulates the growth and differentiation of osteoblast cells, keratinocytes, and MSC cells. This biomarker is administered orally, verified, and widely employed. Learn more about Boster Bio and its products. We will also discuss the ways this biomarker can benefit your research. Whether you're working in a lab or in the field, Boster Bio can help you.

IGF-1 is a growth indicator.

IGF-1 is a growth factor that regulates cell proliferation. In addition, it is an essential component of numerous other proteins found in the body. We studied the effect of IGF-1 on the expression of IFN-gR2 in this study. We discovered that ST4 cells that expressed IGF-1Ra over the surface were more likely proliferate than ST4-DN cell.

ProIGF-1A and proIGF-1B structural domains of human IGF-1 proteins are called proIGF-1A or proIGF-1B. Both proIGF-1Ea (and proIGF-1Ec) contain intrinsically disordered regions known as C-terminal C-domains. ProIGF-1Eb & proIGF-1Ec have a almost identical structure and could be considered putative IDRs.

IGF-1 is a growth hormone with a high affinity for tyrosine kinase receptors. Its phosphorylation and activation of Akt are critical mediators of growth-factor-induced neuronal survival. Brain IGF-1 signaling also inhibits GSK3b, activating anabolic and neuroprotective effects. Many human diseases are connected to the MAP Kinase pathway, which is essential to the survival of neurons. The severity of Parkinson's disease can be reduced by inhibiting the MAP kinase pathway, and the risk of ischemia in the brain is reduced by removing JNK genes.

Although GH/IGF-1 treatment was found to have positive effects in patients suffering from ALS but the results are not conclusive. While there isn't a lot of clinical studies to prove that, the positive effects of this treatment are promising and have the potential to be effective in neurodegenerative disorders. Additionally, IGF-I therapy has an effect on the neurotrophic system and is believed to slow down motor function loss in patients suffering from ALS.

One study revealed that insulin-like growth factor-1 may play a role in arterial essential hypertension. The researchers examined the levels of the hormone in 40 men suffering from newly diagnosed arterial hypertension as well as 15 normotensive control subjects. Patients suffering from arterial essential hypertension had higher levels of IGF-1 than those who were not. However IGF-1 levels in blood were significantly higher in patients with hypertension compared to those of control subjects.

It encourages keratinocytes, MSC and osteoblast cell proliferation

Stem cell biology is dependent on insulin-like growth factors (IGFs). They boost differentiation and encourage self-renewal as well as proliferation. They are found in a variety of cells, but are most abundant in cells of mesodermal origin. MSCs provide IGFs throughout the course of development, and they are thought to contribute to maintaining pluripotency. Recently there have been studies pointing to potential discriminatory effects of IGF-1 and IGF-2 in MSCs.

Human MSCs produce the hormone IGF-1. It is a bone-building hormone by increasing the expression of osteoblast genes and preventing the process of apoptosis. Osteoblast differentiation depends on the presence of IGF-1R. Studies have shown that IGF-1R overexpression speeds up the formation of bone and enhances the mineralization of the matrix. Additionally SHH has been proven to be a positive regulator of IGF-1 signaling osteoblast differentiation. IGF-1-transfected human MSCs boost osteoblast genes and promote bone formation.

MSCs treated with IGF-1 have demonstrated an effect positive on the treatment of myocardial injury and muscular injury. The injection of IGF-1-MSCs improved muscle function and tissue structure and reduced the formation of scars. IGF-1-MSCs also have been proven to enhance MSC proliferation, mobility and decrease Apoptosis. IGF-1 does not however stimulate myocardial differentiation.

IGF1 and MSC cells have been studied as treatments for skin ulcers. Both IGF and MSCs promote wound healing. IGF-1 is expressed in the stratum Granulosum, dermal fibroblasts hair follicles that differentiate, and sebaceous glands, which are crucial in wound healing. In addition, BM-MSCs are used in the treatment of diabetic foot ulcers. They also have improved wound healing and local GF expression.

It is valid

IGF1 is an growth factor that regulates a variety of plant characteristics, including cell growth as well as metabolism and cell differentiation. It is found in many plant tissues such as the pancreas, liver and muscles of the skeletal. Boster Bio has validated this marker by combing it with the chloroplast transformation vector. The resultant marker is a precursor of human IGF-1, with an e-peptide that is synthesized after codon optimizing.

Boster Bio's IGF1 Receptor/IGF1R antibodies are designed to recognize the protein in cells. It has been tested for use in ICC, IHC-P, and IF. It also reacts with Rat, Mouse, and Human cells. It has been tested in a wide range of applications and is readily available. It is also referenced in more than 29,000 scientific articles.

The IGF1 R gene could be utilized in research into tumors. To create a marker for IGF-1R protein expression, the team utilized U87MG cell lines. The miR139 inhibitor can also be used to detect the glioma-cells. This marker targets certain types of glioma cell and is therefore highly specific for tumor cells. The study found that miR-139 decreased IGF-1 R expression in human glioma tumors.

It is not supported by industry

Steven Boster, founder of Boster Bio has a unique background and experience in molecular biology, as well as biotechnology. His early research has earned him the nickname, "he who converts science in the toilet," and he has gone on to develop hundreds of primary antibodies. He was the first catalog antibody from China company, and later developed a unique ELISA platform, PicoKine(tm). These products are now sold worldwide and their sensitivity is unparalleled.

Boster Bio was founded in 1993 and specializes in high-specificity ELISA kits and WB/IHC compatible antibodies. Its recombinant proteins and antibodies are tested and backed with a quality guarantee. The company is expanding their product line every month and their products are patentable. The company doesn't accept any funding from the industry and instead relies on individual requests. Moreover the company does NOT accept stock options.