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- Table of Contents
IGFBP3 Antibodies
AND IGFBP3 ELISA kits, IGFBP3 Proteins
Many biological assays use antibodies to detect IGFBP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IGFBP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IGFBP3 antibodies...
Designing a Western blot for IGFBP3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IGFBP3 Western Blot GuideIGFBP3 Infographic by Boster Bio
All IGFBP3 Products
Product
Figures
Specificity
Applications
Price
Anti-IGFBP3 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # PB9710
100 μg/vial
Cat # PB9710
100 μg/vial
Human
ELISA
$500
Cat # EZ0386
For 5 plates, 96 wells each
Cat # EZ0386
For 5 plates, 96 wells each
IGFBP3 Overview
Facts about Insulin-like growth factor-binding protein 3.
Insulin-like growth factor-binding protein 3 (IGFBP3)
IGF-binding proteins extend the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell membranes.
Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. .
Gene Information
| Human | |
|---|---|
| Gene Name: | IGFBP3 |
| Uniprot: | P17936 |
| Entrez: | 3486 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein; IBP-3; IBP3BP-53; IGF-binding protein 3; IGFBP3; IGFBP-3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3
Molecular Weight
Mass (kDA):
31.674 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p12.3 |
| Sequence: | 7; NC_000007.14 (45912245..45921272, complement) |
Tissue Specificity
Expressed by most tissues. Present in plasma.
Subcellular Localizations
Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Prostate
- Carcinoma
- Growth Disorders
- Prostatic Neoplasms
- Shwachman Syndrome
- Colorectal Cancer
- Obesity
- Colorectal Neoplasms
- Insulin Resistance
Interacting Proteins
- EGFR
- MT-RNR2
- PRKDC
- TMEM219
Pathways
- Cell Proliferation
- Secretion
- Methylation
- Cell Growth
- Pathogenesis
- Dna Methylation
- Cell Cycle
- Angiogenesis
- Aging
- Cell Adhesion
- Localization
- Cell Death
- Hormone Secretion
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Glycosylation
- Demethylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IGFBP3
bosterbio.com/bosterbio-gene-info-cards/IGFBP3
References
PMID: 2464130 by Wood W.I., et al. Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein.
PMID: 1695633 by Cubbage M.L., et al. Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity.
8 Publications of Boster IGFBP3 Antibodies & ELISA Kits
- PubMed ID: 10.3892/mmr.2016.5046, Correlation between insulin‑like growth factor binding protein 3 and metastas...
- PubMed ID: 10.1152/ajpendo.00538.2011, IGF-IR signaling attenuates the age-related decline of diastolic cardiac functio...
- PubMed ID: 22589390, IGF-IR signaling attenuates the age-related decline of diastolic cardiac functio...
- PubMed ID: 28760781, Correlation between insulin%u2011like growth factor binding protein 3 and metast...
- PubMed ID: 29081797, The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Fact...
- PubMed ID: 24204158, Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and...
- PubMed ID: 21595839, Pu Xy, Zheng Xg, Zhang Y, Xiao Hj, Xu Zp, Liu Jm, Wang Hp, Wen Am, Zhou Xx, Wu Y...
- PubMed ID: 24576658, Pu Xy, Wen Am, Liu Jm, Zheng Xg, Xiao Hj, Xu Zp, Wang Hp, Li D, Zhang Rl. J Urol...
*More publications can be found for each product on its corresponding product page