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Mediates the proteolysis-independent signal transduction activation effects of U-PA. It's subject to negative-feedback regulation by U-PA that cleaves it in an inactive form.
|Sequence:||19; NC_000019.10 (43646095..43670346, complement)|
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Cell membrane. Cell projection, invadopodium membrane. Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.; [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 2]: Secreted.