Anti-uPA Receptor/PLAUR Antibody
Rabbit IgG polyclonal antibody for Urokinase plasminogen activator surface receptor(PLAUR) detection. Tested with WB, IHC-P in Human.
Anti-uPA Receptor/PLAUR Antibody Info At A Glance
|Product Name||Anti-uPA Receptor/PLAUR Antibody
See all uPAR primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for uPAR/PLAUR detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. uPAR/PLAUR information: Molecular Weight: 36978 MW; Subcellular Localization: Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner; Tissue Specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.|
|Cite This Product||Anti-uPA Receptor/PLAUR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1344)|
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*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human uPA Receptor(293-304aa CNHPDLDVQYRS).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For PLAUR (Source: Uniprot.org, NCBI)
|NCBI Gene Id||5329|
|Species Of This Entry||Human|
|Protein Name||Urokinase plasminogen activator surface receptor|
|Alternative Names||uPAR|CD87 antigen; CD87; Monocyte activation antigen Mo3; plasminogen activator, urokinase receptor; PLAUR; uPAR; U-PAR; UPARurokinase plasminogen activator surface receptor; u-plasminogen activator receptor form 2; URKRMO3|
|Post Tranlational Modifications||Cleavage; Phosphorylation; Glycosylation; Gpi Anchoring; Biotinylation; Dephosphorylation; Iodination; Deglycosylation; Phosphorothioation; Nitration; Reduction; Acetylation; Amidation; Prenylation; Farnesylation; Methylation; Oxidation|
|Subcellular Localization||Cell membrane. Cell projection, invadopodium membrane. Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.; [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 2]: Secreted.|
|Gene Location||19q13.31, on Chromasome 19, gene sequence: NC_000019.10 (43646095..43670346, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For PLAUR (Source: Uniprot.org, NCBI)
|Protein Function||Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.|
|Tissue Specificity||Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.|
|Interacting Proteins||ANG; PLAU|
|Related Diseases||Neoplasms; Malignant Neoplasms; Cell Invasion; Neoplasm Metastasis; Tissue Adhesions; Carcinoma; Neoplasm Invasiveness; Mammary Neoplasms; Malignant Paraganglionic Neoplasm; Malignant Neoplasm Of Breast; Tumor Angiogenesis; Inflammation; Pathologic Neovascularization; Tumor Progression; Lung Neoplasms; Adenocarcinoma; Malignant Tumor Of Colon; Prostatic Neoplasms; Malignant Neoplasm Of Prostate|
|Related Pathways||Proteolysis; Plasminogen Activation; Cell Migration; Angiogenesis; Cell Adhesion; Localization; Cell Proliferation; Secretion; Fibrinolysis; Pathogenesis; Chemotaxis; Cell Motility; Tissue Remodeling; Wound Healing; Endocytosis; Cell Growth; Regeneration; Tube Formation; Cell Differentiation; Inflammatory Response|
|Background||PLAUR(PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol(GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.|
|Scientific References||PMID: 1689240 by Roldan A.L., et al. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.|
PMID: 1316922 by Min H.Y., et al. cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator.
Our Boster Quality Guarantee for Anti-uPA Receptor/PLAUR Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: MCF-7 Cell Lysate
Lane 2: HELA Cell Lysate
Lane 3: RAJI Cell Lysate
Lane 4: SMMC Cell Lysate
IHC(P): Human Mammary Cancer Tissue
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