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- Table of Contents
Transcription factor Sp1 Antibodies
AND SP1 ELISA kits, Transcription factor Sp1 Proteins
Many biological assays use antibodies to detect Transcription factor Sp1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor Sp1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor Sp1 antibodies...
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SP1 Infographic by Boster Bio
All SP1 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
WB
$370
Cat # RP1072
100 μg/vial
Cat # RP1072
100 μg/vial
Anti-SP1 Antibody Picoband®
3 Citations 17 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00110-1
100 μg/vial
Cat # A00110-1
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1931
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1931
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2122
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2122
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2511
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2511
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00110T739
100ul
Cat # A00110T739
100ul
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00110-2
100 μg/vial
Cat # M00110-2
100 μg/vial
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M00110-3
20μL, 40μL, 100μL, 200μL
Cat # M00110-3
20μL, 40μL, 100μL, 200μL
SP1 Overview
Facts about Transcription factor Sp1.
Transcription factor Sp1 (SP1)
Binds with higher affinity to GC-rich themes and regulates the expression of a large number of genes involved in many different processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).
May have a role in regulating the cellular response to DNA damage. Implicated in chromatin remodeling.
Gene Information
| Human | |
|---|---|
| Gene Name: | SP1 |
| Uniprot: | P08047 |
| Entrez: | 6667 |
Family
| Belongs to: |
|---|
| Sp1 C2H2-type zinc-finger protein family |
Alternative Names
Sp1 transcription factor; specificity protein 1; transcription factor Sp1; TSFP1
Molecular Weight
Mass (kDA):
80.693 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (53380176..53416446) |
Tissue Specificity
Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.
Subcellular Localizations
Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Liver Carcinoma
- Mammary Neoplasms
- Hiv Infections
- Immunologic Deficiency Syndromes
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Leukemia
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- AATF
- CDKN2A
- DLX4
- E2F1
- ELF1
- EPAS1
- ESR1
- HCFC1
- HDAC1
- HIF1A
Pathways
- Methylation
- Cell Cycle
- Translation
- Cell Proliferation
- Cell Growth
- Localization
- Pathogenesis
- Angiogenesis
- Secretion
- Dna Methylation
- Cell Differentiation
- Cell Death
- Transport
PTMs
- Phosphorylation
- Methylation
- Acetylation
- Cleavage
- Dephosphorylation
- Glycosylation
- Demethylation
- Oxidation
- Deacetylation
- Reduction
Research Areas
- Cancer
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP1
bosterbio.com/bosterbio-gene-info-cards/SP1
References
PMID: 21798247 by Infantino V., et al. Identification of a novel Sp1 splice variant as a strong transcriptional activator.
PMID: 10973950 by Takahara T., et al. Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing.
2 Publications of Boster Transcription factor Sp1 Antibodies & ELISA Kits
- PubMed ID: 10.1093/abbs/gmt062, Vascular endothelial growth factor induces multidrug resistance-associated prote...
- PubMed ID: 28678802, miR-182 aids in receptive endometrium development in dairy goats by down-regulat...
*More publications can be found for each product on its corresponding product page