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- Table of Contents
Facts about Sperm-associated antigen 1.
Binds GTP and has GTPase activity. .
| Human | |
|---|---|
| Gene Name: | SPAG1 |
| Uniprot: | Q07617 |
| Entrez: | 6674 |

| Belongs to: |
|---|
| No superfamily |

FLJ32920; HSD-3.8sperm-associated antigen 1; Infertility-related sperm protein Spag-1; SP75; sperm associated antigen 1; tetratricopeptide repeat-containing protein; TPIS; TPR-containing protein involved in spermatogenesis
Mass (kDA):
103.639 kDA

| Human | |
|---|---|
| Location: | 8q22.2 |
| Sequence: | 8; NC_000008.11 (100157869..100241904) |
Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue.
Cytoplasm. Colocalizes with tubulin.




PMID: 11517287 by Lin W., et al. Expression and function of the HSD-3.8 gene encoding a testis- specific protein.
PMID: 1299558 by Zhang M.L., et al. Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility.