4% Paraformaldehyde (PFA) Solution in PBS

antibody

4% Paraformaldehyde solution in PBS is a ready-to-use solution for sample preparation and fixing cells for immunohistochemistry (IHC). Cited in 313 publication(s).

Product Info Summary

SKU: AR1068
Size: From 500mL to 10 x 50mL

General Description

Paraformaldehyde (PFA) is the polymerization product of formaldehyde with a typical degree of polymerization of 8–100 units. Paraformaldehyde is not a fixative itself; it must be depolymerized to formaldehyde in solution. In cell culture, typical formaldehyde fixing procedure would involve using a 4% formaldehyde solution in phosphate buffered saline (PBS) on ice for 10 minutes. Fixing ensures that sample cell structures stay intact and that antigens are immobilized, while ideally still permitting unfettered access of antibodies to target antigens.

Our 4% Paraformaldehyde is the most preferred fixative agent as it builds covalent cross-links between molecules. This glues them together hence effectively preserving cells and tissue components. Use of this 4% paraformaldehyde can guarantee consistency in the physical and chemical properties of the cell, hence no change in chemical and morphology characteristics of the cells and tissues.

Since the 4% paraformaldehyde is not fixative itself, it is required that formaldehyde is freshly prepared from the PFA stock.

Overview

Product Name 4% Paraformaldehyde (PFA) Solution in PBS
SKU/Catalog Number AR1068
FormLiquid
Physical State The solution should be clear, colorless, with no precipitate.
Pack Size 500mL
Application Preserving Samples, Fixing Cells For Histology
*Our Boster Guarantee covers the use of this product in the above tested applications.
StorageStore at -20˚C for one year.
Cite This Product 4% Paraformaldehyde (PFA) Solution in PBS (Boster Biological Technology, Pleasanton CA, USA, Catalog # AR1068)
Equivalent N/A

Properties

CAS Number30525-89-4
MDL NumberMFCD00133991
Solubility Soluble in water
pH 7.0 - 7.6 at 25°C

Safety and Handling

•Causes serious eye damage .

• Suspected of causing cancer.

• May cause an allergic skin reaction.

• Causes skin irritation.

• Avoid breathing dust/fume/gas/mist/vapors/spray.

• Wear protective gloves/protective clothing/eye protection/face protection.

•IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

• Store locked up.

•Dispose of contents/container in accordance with local/regional/national/international regulations.

General Notes

• Adjust pH to 7.2-7.6 with NaH2PO4 if pH <7 after long storage.

• Deposition is normal for this product.

4% Paraformaldehyde Recipe

To prepare a solution of 4% paraformaldehyde you need to use this protocol. The following ingredients are required:

•1M Sodium Hydroxide

•10X phosphate-buffered saline (PBS)

•1M Hydrochloric acid

Note: This should be done in a fume chamber with gloves, safety glasses, and a face mask.

1. To prepare a 4% of paraformaldehyde (PFA) solution in PBS, add 4 grams of granular or prill paraformaldehyde to water (H2O)

2. Use stirring hot plate to heat the solution to 60-degree celsius. Add 1mL of 1M NaOH until the paraformaldehyde is fully dissolved.

3. Add 10 mL of 10x phosphate-buffered saline (PBS) and allow the mixture to cool.

4. Adjust the solution pH with 1M HCL then top up the volume to 100 mL with H2O.

5. Filter the solution to remove any deposit.

Validation Images & Assay Conditions

AR1068 has been cited in 313 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

miR-335 targets CRIM1 to promote the proliferation and inhibit the apoptosis of placental trophoblast cells in preeclamptic rats

LIPUS promotes synthesis and secretion of extracellular matrix and reduces cell apoptosis in human osteoarthritis through upregulation of SOX9 expression

NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer

Effects of epoxyeicosatrienoic acids (EETs) on retinal macular degeneration in rat models.

High expression of SLC26A6 in the kidney may contribute to renal calcification via an SLC26A6-dependent mechanism

LY294002 Induces G0/G1 Cell Cycle Arrest and Apoptosis of Cancer Stem-like Cells from Human Osteosarcoma Via Down-regulation of PI3K Activity

Propranolol induced apoptosis and autophagy via the ROS/JNK signaling pathway in Human Ovarian Cancer

Jiedu Sangen Decoction Reverses Epithelial-to-mesenchymal Transition and Inhibits Invasion and Metastasis of Colon Cancer via AKT/GSK-3β Signaling Pathway

Metformin Inhibits Tumorigenesis and Tumor Growth of Breast Cancer Cells by Upregulating miR-200c but Downregulating AKT2 Expression

Minimally Invasive Surgery for Intracerebral Hematoma Evacuation followed by Rosiglitazone Infusion Therapy Increased Perihematomal Occludin, Zonula Occludens-1 Expression and Decreased the Blood Brain Barrier Permeability in Rabbits

Hippocampal Low-Frequency Stimulation Decreased cAMP Response Element-Binding Protein and Increased GABAA Receptor Subunit α1 in Amygdala-Kindled Pharmacoresistant Epileptic Rats

EZH2 is overexpressed in laryngeal squamous cell carcinoma and enhances the stem-like properties of AMC-HN-8 cells

Expression and clinical significance of Beclin‑1 in gastric cancer tissues of various clinical stages

Salvianolic acid B improves autophagic dysfunction and decreases the apoptosis of cholesterol crystal‑induced macrophages via inhibiting the Akt/mTOR signaling pathway

Atezolizumab alleviates the immunosuppression induced by PD‑L1‑positive neutrophils and improves the survival of mice during sepsis

Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑ mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway

Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus

Lentivirus‑mediated microRNA‑26a overexpression in bone mesenchymal stem cells facilitates bone regeneration in bone defects of calvaria in mice

Translocation of enterohemorrhagic Escherichia coli effector Tir to the plasma membrane via host Golgi apparatus

Pioglitazone affects the OPG/RANKL/RANK system and increase osteoclastogenesis

Shox2 influences mesenchymal stem cell fate in a co-culture model in vitro

Indirect co‑culture of vascular smooth muscle cells with bone marrow mesenchymal stem cells inhibits vascular calcification and downregulates the Wnt signaling pathways

Radioresistance of granulation tissue-derived cells from skin wounds combined with total body irradiation

Chronic sciatic nerve compression induces fibrosis in dorsal root ganglia

Neuronic autophagy contributes to p-connexin 43 degradation in hippocampal astrocytes following traumatic brain injury in rats

Erythropoietin ameliorates renal interstitial fibrosis via the inhibition of fibrocyte accumulation

Resveratrol abrogates the effects of hypoxia on cell proliferation, invasion and EMT in osteosarcoma cells through downregulation of the HIF-1α protein

GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer

Although c‑MYC contributes to tamoxifen resistance, it improves cisplatin sensitivity in ER‑positive breast cancer

MALAT1 promotes liver fibrosis by sponging miR‑181a and activating TLR4‑NF‑κB signaling

Simvastatin inhibits the adipogenesis of bone marrow‑derived mesenchymal stem cells through the downregulation of chemerin/CMKLR1 signaling

MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3

In vivo effects of the NLRP1/NLRP3 inflammasome pathway on latent respiratory virus infection

LINC00473 exacerbates osteoarthritis development by promoting chondrocyte apoptosis and proinflammatory cytokine production through the miR‑424‑5p/LY6E axis

Construction and evaluation of a novel tissue‑engineered bone device

Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats

Expression of hypoxia‑inducible factor 3α in hepatocellular carcinoma and its association with other hypoxia‑inducible factors

Electric pulse current stimulation increases electrophysiological properties of If current reconstructed in mHCN4-transfected canine mesenchymal stem cells

Effect of advanced glycation end products on the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor proteins in RF/6A cells

Neuroprotective effect of recombinant human erythropoietin on optic nerve injury in rats

Mesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism

Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet

Sheng-jiang powder ameliorates obesity-induced pancreatic inflammatory injury via stimulating activation of the AMPK signalling pathway in rats

Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune Evasion

Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling

A Bioactive Compound from Sanguisorba officinalis L. Inhibits Cell Proliferation and Induces Cell Death in 5-Fluorouracil-Sensitive/Resistant Colorectal Cancer Cells

Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1

A Cell-Based Platform for the Investigation of Immunoproteasome Subunit β5i Expression and Biology of β5i-Containing Proteasomes

Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor

Human Olfactory Mesenchymal Stem Cells Are a Novel Candidate for Neurological Autoimmune Disease.

Safflower Yellow and Its Main Component HSYA Alleviate Diet-Induced Obesity in Mice: Possible Involvement of the Increased Antioxidant Enzymes in Liver and Adipose Tissue

CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer’s Disease

Probiotic administration of lactobacillus rhamnosus GR-1 attenuates atherosclerotic plaque formation in ApoE-/- mice fed with a high-fat diet.

Transplantation of BDNF Gene Recombinant Mesenchymal Stem Cells and Adhesive Peptide-modified Hydrogel Scaffold for Spinal Cord Repair

Metabolic Conversion and Removal of Manganese Ferrite Nanoparticles in RAW264.7 Cells and Induced Alteration of Metal Transporter Gene Expression

In vitro and in vivo biocompatibility and osteogenesis of graphene-reinforced nanohydroxyapatite polyamide66 ternary biocomposite as orthopedic implant material

Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro

H subtype vascular endothelial cells in human femoral head: an experimental verification.

Knockdown of long non-coding RNA LCPAT1 inhibits autophagy in lung cancer

Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver

MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K/Akt/eNOS signaling pathway

Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma

Differential expression of androgen, estrogen, and progesterone receptors in benign prostatic hyperplasia

The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model

Chondroprotective Effects of Combination Therapy of Acupotomy and Human Adipose Mesenchymal Stem Cells in Knee Osteoarthritis Rabbits via the GSK3β-Cyclin D1-CDK4/CDK6 Signaling Pathway

Development of a Xeno-Free Feeder-Layer System from Human Umbilical Cord Mesenchymal Stem Cells for Prolonged Expansion of Human Induced Pluripotent Stem Cells in Culture

The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis

Polydatin Improves Glucose and Lipid Metabolisms in Insulin-Resistant HepG2 Cells through the AMPK Pathway

A SNP-mediated lncRNA ( LOC146880 ) and microRNA (miR-539-5p) interaction and its potential impact on the NSCLC risk

Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in Gynostemma pentaphylla (Thunb.) Makino treated mice

Biomimetic oxygen delivery nanoparticles for enhancing photodynamic therapy in triple-negative breast cancer

Early-stage minimally invasive procedures decrease perihematomal endothelin-1 levels and improve neurological functioning in a rabbit model of intracerebral hemorrhage

The perihematomal glutamate level is associated with the outcome of patients with basal ganglia hematomas treated by inimally invasive procedures

Preparation and characterization of conductive nerve guide conduit filled with dual drug-loaded nanofibers:

Adult Stem Cells Seeded on Electrospinning Silk Fibroin Nanofiberous Scaffold Enhance Wound Repair and Regeneration

β-Cyclodextrin-Linked Polyethylenimine Nanoparticles Facilitate Gene Transfer and Enhance the Angiogenic Capacity of Mesenchymal Stem Cells for Wound Repair and Regeneration

LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells

Long Non-Coding RNA-MALAT1 Mediates Retinal Ganglion Cell Apoptosis Through the PI3K/Akt Signaling Pathway in Rats with Glaucoma

Comparison of the Proliferation, Viability, and Differentiation Capacity of Adipose-Derived Stem Cells from Different Anatomic Sites in Rabbits

Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction

Acupotomy Contributes to Suppressing Subchondral Bone Resorption in KOA Rabbits by Regulating the OPG/RANKL Signaling Pathway

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro

The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation

Mesenchymal Stem Cells Attract Endothelial Progenitor Cells via a Positive Feedback Loop between CXCR2 and CXCR4

Bone Marrow-Derived CD44+ Cells Migrate to Tissue-Engineered Constructs via SDF-1/CXCR4-JNK Pathway and Aid Bone Repair

Jiedu Sangen Decoction Inhibits the Invasion and Metastasis of Colorectal Cancer Cells by Regulating EMT through the Hippo Signaling Pathway

Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

Periplaneta americana peptide decreases apoptosis of pig-ovary granulosa cells induced by H2O2 through FoxO1

ILK regulates osteogenic differentiation of Human Periodontal Ligament Stem Cells through YAP-mediated Mechanical Memory

Tetrahedral DNA nanostructures facilitate neural stem cell migration via activating RHOA/ROCK2 signalling pathway

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model

The presence and expression of the hepatitis B virus in human oocytes and embryos

Preparation and Characterization of a Chitosan/Gelatin/Extracellular Matrix Scaffold and Its Application in Tissue Engineering

Rapid Differentiation of Multi-Zone Ocular Cells from Human Induced Pluripotent Stem Cells and Generation of Corneal Epithelial and Endothelial Cells

A versatile modular preparation strategy for targeted drug delivery systems against multidrug-resistant cancer cells

Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway

Lithium chloride promotes proliferation of neural stem cells in vitro, possibly by triggering the Wnt signaling pathway

Resveratrol improves osteogenic differentiation of senescent bone mesenchymal stem cells through inhibiting endogenous reactive oxygen species production via AMPK activation

Effect of klotho as an ageing suppressor on insulin signalling cascade in brain of d-galactose mice by Yisui moxibustion

Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles

Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism

High orexin-A neuron activity and RACK1 expression might be involved in the restricted feeding-entrained behaviors in mice

Nanoscaled pearl powder accelerates wound repair and regeneration in vitro and in vivo

Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo

Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways

Hippocampal low-frequency stimulation inhibits afterdischarge and increases GABA (A) receptor expression in amygdala-kindled pharmacoresistant epileptic rats

Sperm storage in the oviduct of the Chinese pond turtle Mauremys reevesii depends on oestrogen-based suppression of the TLR2/4 immune pathway

Effect of grapeseed procyanidins on small intestinal mucosa morphology and small intestinal development in weaned piglets

Combination of dihydroartemisinin and resveratrol effectively inhibits cancer cell migration via regulation of the DLC1/TCTP/Cdc42 pathway

Beneficial effects of combination therapy of phloretin and metformin in streptozotocin-induced diabetic rats and improved insulin sensitivity in vitro

Paclitaxel-loaded pluronic F127/P123 silica nanocapsules with surface conjugated rhTRAIL for targeted cancer therapy

Conformal microcapsules encapsulating microcarrier-L02 cell complexes for treatment of acetaminophen-induced liver injury in rats

Fabrication and in vivo chondrification of a poly(propylene carbonate)/L-lactide-grafted tetracalcium phosphate electrospun scaffold for cartilage tissue engineering

The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway

miR-30d suppresses proliferation and invasiveness of pancreatic cancer by targeting the SOX4/PI3K-AKT axis and predicts poor outcome

A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR

Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1

SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway

Transcriptome analysis reveals dysregulation of genes involved in oxidative phosphorylation in a murine model of retinopathy of prematurity

Short- and long-term impact of hyperoxia on the blood and retinal cells’ transcriptome in a mouse model of oxygen-induced retinopathy

Sequence-Dependent Synergistic Inhibition of Human Glioma Cell Lines by Combined Temozolomide and miR-21 Inhibitor Gene Therapy

Chitosan-Gelatin Scaffolds Incorporating Decellularized Platelet-Rich Fibrin Promote Bone Regeneration

DNA-Based Nanomedicine with Targeting and Enhancement of Therapeutic Efficacy of Breast Cancer Cells

Graphdiyne Nanoparticles with High Free Radical Scavenging Activity for Radiation Protection

Self-Assembled Tetrahedral DNA Nanostructures Promote Neural Stem Cell Proliferation and Neuronal Differentiation

Gold Nanoclusters–Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment, and Real-Time Monitoring Based on Fluorescence Resonance Energy Transfer

Peptide-Tethered Hydrogel Scaffold Promotes Recovery from Spinal Cord Transection via Synergism with Mesenchymal Stem Cells

Self-Assembled Tetrahedral DNA Nanostructures Promote Adipose-Derived Stem Cell Migration via lncRNA XLOC 010623 and RHOA/ROCK2 Signal Pathway

pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery

Hyaluronic Acid-Modified Multifunctional Q-Graphene for Targeted Killing of Drug-Resistant Lung Cancer Cells

Organic Near-Infrared-II Nanophotosensitizer for Safe Cancer Phototheranostics and Improving Immune Microenvironment against Metastatic Tumor

Co-delivery of Pirarubicin and Paclitaxel by Human Serum Albumin Nanoparticles to Enhance Antitumor Effect and Reduce Systemic Toxicity in Breast Cancers

The feedback loop of “EMMPRIN/NF-κB” worsens atherosclerotic plaque via suppressing autophagy in macrophage

Peri-implantation expression and regulation of ITGB8 in goat uterus

Involvement of m6A regulatory factor IGF2BP1 in malignant transformation of human bronchial epithelial Beas-2B cells induced by tobacco carcinogen NNK

Programmed microcapsule-type matrix metalloproteinase-2 (MMP-2)-responsive nanosensor for in situ monitoring of intracellular MMP-2

Dichlorvos poisoning caused chicken cerebrum tissue damage and related apoptosis-related gene changes

Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes

miR-150-5p mediates extravillous trophoblast cell migration and angiogenesis functions by regulating VEGF and MMP9

Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum

Diphenyleneiodonium enhances P2X7 dependent non-opsonized phagocytosis and suppresses inflammasome activation via blocking CX43-mediated ATP leakage

Touchscreen tasks in mice to demonstrate differences between hippocampal and striatal functions

LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells

Geniposide effectively reverses cognitive impairment and inhibits pathological cerebral damage by regulating the mTOR Signal pathway in APP∕PS1 mice

Robust anti-infective multilayer coatings with rapid self-healing property

Bio-multifunctional alginate/chitosan/fucoidan sponges with enhanced angiogenesis and hair follicle regeneration for promoting full-thickness wound healing

Fabrication and characterization of porous polycaprolactone scaffold via extrusion-based cryogenic 3D printing for tissue engineering

FosB recruits KAT5 to potentiate the growth and metastasis of papillary thyroid cancer in a DPP4-dependent manner

MicroRNA-92a serves as a risk factor in sepsis-induced ARDS and regulates apoptosis and cell migration in lipopolysaccharide-induced HPMEC and A549 cell injury

Cinobufagin induced cell apoptosis and protective autophagy through the ROS/MAPK signaling pathway

The Protective Effects of 17β-Estradiol on Hepatic Ischemia–Reperfusion Injury in Rat Model, Associated with Regulation of Heat-Shock Protein Expression

Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells

Quercetin confers protection of murine sepsis by inducing macrophage M2 polarization via the TRPM2 dependent calcium influx and AMPK/ATF3 activation

α-Cyperone inhibitory effects on tumor-derived DNA trigger microglia by STING pathway

Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice

Metabolomics analysis of Danggui Sini decoction on treatment of collagen-induced arthritis in rats

Schisandrin A and B affect the proliferation and differentiation of neural stem cells

Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis

Inhibition of microRNA-92a ameliorates lipopolysaccharide-induced endothelial barrier dysfunction by targeting ITGA5 through the PI3K/Akt signaling pathway in human pulmonary microvascular endothelial cells

BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma

Pravastatin alleviates interleukin 1β-induced cartilage degradation by restoring impaired autophagy associated with MAPK pathway inhibition

Construction of a biomimetic chemokine reservoir stimulates rapid in situ wound repair and regeneration

Uniformly sized iron oxide nanoparticles for efficient gene delivery to mesenchymal stem cells

Design of magnetic gene complexes as effective and serum resistant gene delivery systems for mesenchymal stem cells

Silk fibroin/gelatin electrospun nanofibrous dressing functionalized with astragaloside IV induces healing and anti-scar effects on burn wound

Female hormone release of microencapsulated Xenopus laevis ovarian cells

Astragaloside IV-loaded nanoparticle-enriched hydrogel induces wound healing and anti-scar activity through topical delivery

Characteristics of sequential targeting of brain glioma for transferrin-modified cisplatin liposome

Sulfated polysaccharide from Undaria pinnatifida stabilizes the atherosclerotic plaque via enhancing the dominance of the stabilizing components

Inhibition of autophagy by YC-1 promotes gefitinib induced apoptosis by targeting FOXO1 in gefitinib-resistant NSCLC cells

Topical application of Hydroxysafflor Yellow A accelerates the wound healing in streptozotocin induced T1DM rats

Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway

Porous microspheres as promising vehicles for the topical delivery of poorly soluble asiaticoside accelerate wound healing and inhibit scar formation in vitro & in vivo

Investigating the effect of nitrate on juvenile turbot (Scophthalmus maximus) growth performance, health status, and endocrine function in marine recirculation aquaculture systems

Effects of chronic nitrate exposure on the intestinal morphology, immune status, barrier function, and microbiota of juvenile turbot (Scophthalmus maximus)

LncRNA PICSAR promotes cell proliferation, migration and invasion of fibroblast-like synoviocytes by sponging miRNA-4701-5p in rheumatoid arthritis

The effects of long-term exposure to low doses of cadmium on the health of the next generation of mice

Preparation of triamcinolone acetonide-loaded chitosan/fucoidan hydrogel and its potential application as an oral mucosa patch

Minimally invasive procedures for intracerebral hematoma evacuation in early stages decrease perihematomal glutamate level and improve neurological function in a rabbit model of ICH

Evaluation of efficacy of aloin in treating acute trauma in vitro and in vivo

An antibody-like peptidic network for anti-angiogenesis

Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc/CD47 axis

Lovastatin enhances chemosensitivity of paclitaxel-resistant prostate cancer cells through inhibition of CYP2C8

Involvement of prostatic interstitial cells of Cajal in inflammatory cytokines-elicited catecholamines production: Implications for the pathophysiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)

Low-intensity pulsed ultrasound inhibits IL-6 in subchondral bone of temporomandibular joint osteoarthritis by suppressing the TGF-β1/Smad3 pathway

Exposure to hydroxyapatite nanoparticles enhances Toll-like receptor 4 signal transduction and overcomes endotoxin tolerance in vitro and in vivo

Metformin enhances gefitinib efficacy by interfering with interactions between tumor-associated macrophages and head and neck squamous cell carcinoma cells

Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus

Minimally Invasive Procedures for Evacuation of Intracerebral Hemorrhage Reduces Perihematomal Glutamate Content, Blood–Brain Barrier Permeability and Brain Edema in Rabbits

Effects of Fluoride on Autophagy in Mouse Sertoli Cells

The Effect of Chronic Fluorosis on Calcium Ions and CaMKIIα, and c-fos Expression in the Rat Hippocampus

Sub-cytotoxic concentrations of ionic silver promote the proliferation of human keratinocytes by inducing the production of reactive oxygen species

ERβ modulates genistein’s cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway

Rhoifolin Alleviates Inflammation of Acute Inflammation Animal Models and LPS-Induced RAW264.7 Cells via IKKβ/NF-κB Signaling Pathway

Downregulation of Paralemmin-3 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Rats by Regulating Inflammatory Response and Inhibiting Formation of TLR4/MyD88 and TLR4/TRIF Complexes

Robust and Self-healable Antibiofilm Multilayer Coatings

Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing

Characterization of rabbit urine-derived stem cells for potential application in lower urinary tract tissue regeneration

PLGA-based control release of Noggin blocks the premature fusion of cranial sutures caused by retinoic acid

Single-cell transcriptomic sequencing analyses of cell heterogeneity during osteogenesis of human adipose-derived mesenchymal stem cells

Carbonized polymer dots with dual‐wavelength emission for labeling nucleoli in live cells through hydrogen bonding‐induced aggregation

Low‐intensity pulsed ultrasound protects subchondral bone in rabbit temporomandibular joint osteoarthritis by suppressing TGF‐β1/Smad3 pathway

Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling

LncRNA NEAT1_1 suppresses tumor-like biologic behaviors of fibroblast-like synoviocytes by targeting the miR-221-3p/uPAR axis in rheumatoid arthritis

Calcium‐activated nucleotidase 1 silencing inhibits proliferation, migration, and invasion in human clear cell renal cell carcinoma

AT1R knockdown confers cardioprotection against sepsis‐induced myocardial injury by inhibiting the MAPK signaling pathway in rats

FUT11 is a target gene of HIF1α that promotes the progression of hepatocellular carcinoma

The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinsons disease more effectively than the GLP-1 single-receptor agonist NLY01

The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinsons disease more effectively than the GLP-1 single-receptor agonist NLY01

The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinsons disease more effectively than the GLP-1 single-receptor agonist NLY01

Glioma targeting and blood–brain barrier penetration by dual-targeting doxorubincin liposomes

Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing

A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation

Graphdiyne nanoradioprotector with efficient free radical scavenging ability for mitigating radiation-induced gastrointestinal tract damage

Inhibiting Methicillin-Resistant Staphylococcus aureus by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery

Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

Monosized Polymeric Microspheres Designed for Passive Lung Targeting: Biodistribution and Pharmacokinetics after Intravenous Administration

Lv M,Xue G,Cheng H,Meng P,Lian X,Hölscher C,Li D. The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinson‘s disease more effectively than the GLP-1 single-receptor agonist NLY01. Brain Behav. 2021 Jun 14. doi: 10.1002/brb3.2231. Epub ahead of print. PMID: 34125470.
Species: Mouse
AR1068 usage in article: APP:IHC, SAMPLE:BRAIN TISSUE, DILUTION:NA

Zhang Y,Zhang R,Ge L,Wang L.Exosome-derived TXNDC5 is Required for the Inflammatory Progression of Rheumatoid Arthritis Fibroblast-like Synoviocytes.Explor Res Hypothesis Med.Published online:May 20,2021.doi:10.14218/ERHM.2021.00013.
Species: Human
AR1068 usage in article: APP:FLOW CYTOMETRY, SAMPLE:RA-FLS, DILUTION:NA

Chen X,Yue J,Luo Y,Huang L,Li B,Wen S.Distinct behavioral traits and associated brain regions in mouse models for obsessive-compulsive disorder.Behav Brain Funct.2021 May 18;17(1):4.doi:10.1186/s12993-021-00177-x.PMID:34006308;PMCID:PMC8132448.
Species: Mouse
AR1068 usage in article: APP:IF, SAMPLE:BRAIN TISSUE, DILUTION:NA

Tong Wang,Yan Guo,Xiao-Wei Shi,Yang Gao,Jia-Yi Zhang,Chun-Jiu Wang,Xue Yang,Qi Shu,Xi-Lin Chen,Xin-Yi Fu,Wen-Shan Xie,Yi Zhang,Bin Li,Chang-Qing Guo, "Acupotomy Contributes to Suppressing Subchondral Bone Resorption in KOA Rabbits by Regulating the OPG/RANKL Signaling Pathway",Evidence-Based Complementary and Alternative Medicine,vol.2021, Article ID 8168657,17 pages,2021.https://doi.org/10.1155/2021/8168657
Species: New Zealand White Rabbit
AR1068 usage in article: APP:IHC, SAMPLE:FEMUR TISSUE, DILUTION:NA

Yueming Gu,Guyue Li,Cheng Huang,Pei Liu,Guoliang Hu,Cong Wu,Zheng Xu,Xiaoquan Guo,Ping Liu,Dichlorvos poisoning caused chicken cerebrum tissue damage and related apoptosis-related gene changes,Science of The Total Environment,Volume 783,2021,147051,ISSN 0048-9697,https://doi.org/10.1016/j. scitotenv.2021.147051.
Species: Broiler
AR1068 usage in article: APP:IHC, SAMPLE:CEREBRUM, DILUTION:NA

Lu X,Liang B,Li S,Chen Z,Chang W.Modulation of HOXA9 after skeletal muscle denervation and reinnervation.Am J Physiol Cell Physiol.2020 Jun 1;318(6):C1154-C1165.doi:10.1152/ajpcell.00055.2020.Epub 2020 Apr 1.PMID:32233950.
Species: Rat
AR1068 usage in article: APP:IF, SAMPLE:PRIMARY SATELLITE CELL, DILUTION:NA

Xu X,Zong K,Wang X,Dou D,Lv P,Zhang Z,Li H.miR-30d suppresses proliferation and invasiveness of pancreatic cancer by targeting the SOX4/PI3K-AKT axis and predicts poor outcome.Cell Death Dis.2021 Apr 6;12(4):350.doi:10.1038/s41419-021-03576-0.PMID:33824274.
Species: Human,Mouse
AR1068 usage in article: APP:IF, SAMPLE:PANCREATIC CELLS, DILUTION:NA

Xu Q,Sun L, Zhang W,Wu H,Jiao C,Xu L,Qian X,Yao H,Chen Q,Xu F,Fu F,Feng Y,Wang L,Chen X.A novel visceral pain model of uterine cervix inflammation in rat.Eur J Pharmacol.2021 Mar 31;900:174080.doi:10.1016/j.ejpha r.2021.174080.Epub ahead of print.PMID:33811839.
Species: Rat
AR1068 usage in article: APP:ICC, SAMPLE:SPINAL CORD TISSUE, DILUTION:NA

Xin Yi, Jie Liu, Mo-sha Cheng, Qing Zhou,Low-intensity pulsed ultrasound inhibits IL-6 in subchondral bone of temporomandibular joint osteoarthritis by suppressing the TGF-β1/Smad3 pathway,Archives of Oral Biology,2021,105110,ISSN 0003-9969,https://doi.org/10.1016/j.archoralbio.2021.105110.
Species: New Zealand White Rabbit,Mouse
AR1068 usage in article: APP:IF, SAMPLE:MC3T3-E1 CELL, DILUTION:NA

Cao N,Tang X,Gao R,Kong L,Zhang J,Qin W,Hu N,Zhang A,Ma K,Li L,Si JQ. Galectin-3 participates in PASMC migration and proliferation by interacting with TGF-β1. Life Sci. 2021 Mar 11:119347. doi: 10.1016/j.lfs.2021.119347.Epub ahead of print.PMID:33716065.
Species: Human,Rat
AR1068 usage in article: APP:IF, SAMPLE:HPASMCS, DILUTION:NA

Zhang C,Liu W,Li F,Feng Y,Li Y,Wang J. Hsa_circ_0015326 Promotes the Proliferation, Invasion and Migration of Ovarian Cancer Through miR-127-3p/MYB. Cancer Manag Res. 2021 Mar 10;13:2265-2277.doi:10.2147/CMAR.S291218.PMID:33732019;PMCID:PMC7956866.
Species: Human,Mouse
AR1068 usage in article: APP:COLONY FORMATION ASSAY, SAMPLE:A2780 CELL AND SKOV3 CELL, DILUTION:NA

Zhu Q,Li Y,Dong X,Yang Y,Wang H,Guo S.Linc-OIP5 loss regulates migration and invasion in MDA-MB-231 breast cancer cells by inhibiting YAP1/JAG1 signaling.Oncol Lett.2020 Jan;19(1):103-112.doi:10.3892/ol.2019.11071.Epub 2019 Nov 8.PMID:31897120;PMCID:PMC69
Species: Human
AR1068 usage in article: APP:IF, SAMPLE:MDA-MB-231 CELL AND MCF-7 CELL, DILUTION:NA

Chemical Components and Hepatoprotective Mechanism of Xwak Granule in Mice Treated with Acute Alcohol. Hui Zheng,Hengyi Yan
Species: Rat
AR1068 usage in article: APP:IF, SAMPLE:LIVER TISSUE, DILUTION:NA

Yi X,Wu L,Liu J,Qin YX,Li B,Zhou Q.Low-intensity pulsed ultrasound protects subchondral bone in rabbit temporomandibular joint osteoarthritis by suppressing TGF-β1/Smad3 pathway.J Orthop Res.2020 Nov;38(11):2505-2512.doi:10.1002/jor.24628.Epub 2020 Feb 26
Species: New Zealand Rabbit
AR1068 usage in article: APP:IHC, SAMPLE:CONDYLE TISSUE, DILUTION:NA

Zhang R,Meng F,Zhang Q,Zou Z,Xiao K,Zhu T,Li H,Zhang W,Ma J,Ma J.Allogeneic adipose-derived mesenchymal stem cells promote the expression of chondrocyte redifferentiation markers and retard the progression of knee osteoarthritis in rabbits. Am J Transl Re
Species: New Zealand Rabbit
AR1068 usage in article: APP:IF, SAMPLE:ADSCS, DILUTION:NA

Su,Y.,Zeng,Z.,Rong,D.,Yang,Y.,Wu,B.,& Cao,Y.(2021).PSMC2, ORC5 and KRTDAP are specific biomarkers for HPV‑negative head and neck squamous cell carcinoma.Oncology Letters,21,289.https://doi.org/10.3892/ol.2021.1255
Species: Human
AR1068 usage in article: APP:IHC, SAMPLE:HNSCC TISSUE, DILUTION:NA

Chen R,Guo S,Yang C,Sun L,Zong B,Li K,Liu L,Tu G,Liu M,Liu S.Although c‑MYC contributes to tamoxifen resistance, it improves cisplatin sensitivity in ER‑positive breast cancer.Int J Oncol.2020 Apr;56(4):932-944.doi:10.3892/ijo.2020.4987.Epub 2020 Feb 14.P
Species: Human
AR1068 usage in article: APP:CELL INVASION ASSAY, SAMPLE:MCF7 CELL AND T47D CELL, DILUTION:NA

Zhu Y,Chen X,Lu Y,Fan S,Yang Y,Chen Q,Huang Q,Xia L,Wei Y,Zheng J,Liu X.Diphenyleneiodonium enhances P2X7 dependent non - opsonized phagocytosis and suppresses inflammasome activation via blocking CX43 - mediated ATP leakage.Pharmacol Res.2021 Jan 30:1054
Species: Mouse
AR1068 usage in article: APP:IHC, SAMPLE:LUNG AND LIVER TISSUE, DILUTION:NA

Cheng JN,Luo W,Sun C,Jin Z,Zeng X,Alexander PB,Gong Z,Xia X,Ding X,Xu S,Zou P,Wan YY,Jia Q,Li QJ,Zhu B.Radiation-induced eosinophils improve cytotoxic T lymphocyte recruitment and response to immunotherapy.Sci Adv.2021 Jan 29;7(5):eabc7609.doi:10.1126/sci
Species: Human,Mouse
AR1068 usage in article: APP:IF, SAMPLE:LUNG TISSUE, DILUTION:NA

Xu Z,Gao J,Yao J,Yang T,Wang D,Dai C,Ding Y.Preclinical efficacy and toxicity studies of a highly specific chimeric anti-CD47 antibody.FEBS Open Bio.2021 Jan 15.doi:10.1002/2211-5463.13084.Epub ahead of print.PMID:33449453.
Species: Human,Mouse
AR1068 usage in article: APP:FLOW CYTOMETRY, SAMPLE:CD47 CELL, DILUTION:NA

Jiachen Yu,Yanfeng Wang,Yongshuang Xiao,Xian Li,Li Zhou,Yunong Wang,Tengfei Du,Xiaona Ma,Jun Li,Investigating the effect of nitrate on juvenile turbot (Scophthalmus maximus) growth performance, health status, and endocrine function in marine recirculation
Species: juvenile turbot
AR1068 usage in article: APP:IHC, SAMPLE:GILL AND LIVER, DILUTION:NA

Chen, J.,Chen, R.,Huang, S.,Zu, B., & Zhang, S.(2021). Atezolizumab alleviates the immunosuppression induced by PD‑L1‑positive neutrophils and improves the survival of mice during sepsis. Molecular Medicine Reports, 23,144.https://doi.org/10.3892/mmr.2020
Species: Mouse
AR1068 usage in article: APP:IHC, SAMPLE:ILEUM TISSUE, DILUTION:NA

Zeng Z, Lan J, Lei S, Yang Y, He Z, Xue Y, Chen T. Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells. Onco Targets Ther. 2020 Nov 17;13:11697-11709. doi: 10.2147/O
Species: Human
AR1068 usage in article: APP:IHC, SAMPLE:HCC CELLS, DILUTION:NA

He J, Su X, Xie W. MiR-582-3p alleviates osteoarthritis progression by targeting YAP1. Mol Immunol. 2020 Nov 12;128:258-267. doi: 10.1016/j.molimm.2020.10.022. Epub ahead of print. PMID: 33190006.
Species: Human, Rat
AR1068 usage in article: APP:IHC, SAMPLE:JOINT TISSUES, DILUTION:NA

Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on %u2026

PLGA-based control release of Noggin blocks the premature fusion of cranial sutures caused by retinoic acid

Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats

Influence of high-altitude hypoxic environments on the survival of cochlear hair cells and spiral ganglion neurons in rats

The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway

Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light

MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K/Akt/eNOS signaling pathway

Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway

Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1

In vitro and in vivo biocompatibility and osteogenesis of graphene-reinforced nanohydroxyapatite polyamide66 ternary biocomposite as orthopedic implant material

EZH2 is overexpressed in laryngeal squamous cell carcinoma and enhances the stem-like properties of AMC-HN-8 cells

LmCYP4G102: An oenocyte-specific cytochrome P450 gene required for cuticular waterproofing in the migratory locust, Locusta migratoria

Effects of fluoride on proliferation and mineralization in periodontal ligament?cells?in vitro

Microvesicles derived from hypoxia/reoxygenation-treated human umbilical vein endothelial cells promote apoptosis and oxidative stress in H9c2 cardiomyocytes

Differential expression of androgen, estrogen, and progesterone receptors in benign prostatic hyperplasia

Right coronary artery fistula misdiagnosed as right atrial cardiac myxoma: A case report

Shox2 influences mesenchymal stem cell fate in a co-culture model in?vitro

Astragalus membranaceus?ameliorates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition?in vivo?and?in vitro

Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer drug repurposing

Electric pulse current stimulation increases electrophysiological properties of If?current reconstructed in mHCN4-transfected canine mesenchymal stem cells

Expression and clinical significance of Beclin-1 in gastric cancer tissues of various clinical stages

Improved prescription of taohechengqi-tang alleviates D-galactosamine acute liver failure in rats

Development of a Xeno-Free Feeder-Layer System from Human Umbilical Cord Mesenchymal Stem Cells for Prolonged Expansion of Human Induced Pluripotent Stem Cells in Culture

Impacts of Rho kinase inhibitor Fasudil on Rho/ROCK signaling pathway in rabbits with optic nerve injury

Chronic sciatic nerve compression induces fibrosis in dorsal root ganglia

The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis

Cellular response of chondrocytes to magnesium alloys for orthopedic applications

Sequential release of salidroside and paeonol from a nanosphere-hydrogel system inhibits ultraviolet B-induced melanogenesis in guinea pig skin

Effects of minimally invasive procedures for evacuation of intracerebral hematoma in early stages on MMP-9 and BBB permeability in rabbits

Perihematomal glutamate level is associated with the blood?brain barrier disruption in a rabbit model of intracerebral hemorrhage

Effect of advanced glycation end products on the expression of hypoxia-inducible factor-1? and vascular endothelial growth factor proteins in RF/6A cells

Lin L, Jia Z, Zhao Y, Wu Y, Zhao X, Li Y, Guo Z, Chen J, Cheng S, Wang D, Ruan D. Biomed Res Int. 2017;2017:9765843. doi: 10.1155/2017/9765843. Epub 2017 Oct 8. Use of Limiting Dilution Method for Isolation of Nucleus Pulposus Mesenchymal Stem/Pr...

Yu X, Lin H, Wang Y, Lv W, Zhang S, Qian Y, Deng X, Feng N, Yu H, Qian B. Onco Targets Ther. 2018 Apr 4;11:1833-1847. doi: 10.2147/OTT.S155716. eCollection 2018. d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung ca...

Mo BY, Guo XH, Yang MR, Liu F, Bi X, Liu Y, Fang LK, Luo XQ, Wang J, Bellanti JA, Pan YF, Zheng SG. Front Immunol. 2018 Apr 10;9:702. doi: 10.3389/fimmu.2018.00702. eCollection 2018. Long Non-Coding RNA GAPLINC Promotes Tumor-Like Biologic Behavio...

Liu Q, Sun B, Zhao J, Wang Q, An F, Hu X, Yang Z, Xu J, Tan M, Li L. Exp Mol Med. 2018 May 7;50(5):60. doi: 10.1038/s12276-018-0088-z. Increased Piezo1 channel activity in interstitial Cajal-like cells induces bladder hyperactivity by functionally...

Chen WZ, Li YM, Yu X, Li Y, Li WK, Wang QL, Liang AX, Li X, Yang LG, Han L. Microb Biotechnol. 2018 Jan;11(1):248-256. doi: 10.1111/1751-7915.13029. Epub 2017 Dec 4. The efficacy, biodistribution and safety of an inhibin DNA vaccine delivered by a...

Li K, Gesang L, He C. Exp Ther Med. 2017 Oct;14(4):3780-3787. doi: 10.3892/etm.2017.4996. Epub 2017 Aug 22. Mechanism of apoptosis involved in gastric mucosal lesions in Tibetans with high-altitude polycythemia

Li J, Deng J, Yuan J, Fu J, Li X, Tong A, Wang Y, Chen Y, Guo G. Int J Nanomedicine. 2017 Mar 29;12:2443-2456. doi: 10.2147/IJN.S128705. eCollection 2017. Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the tr...

Fang X, Li Y, Qiao J, Guo Y, Miao M. Mol Med Rep. 2017 Nov;16(5):7439-7449. doi: 10.3892/mmr.2017.7540. Epub 2017 Sep 20. Neuroprotective effect of total flavonoids from Ilex pubescens against focal cerebral ischemia/reperfusion injury in rats

Jiang Y, Zhao Y, Chen S, Chen L, Li C, Zhou X. Reprod Biol Endocrinol. 2018 Mar 20;16(1):25. doi: 10.1186/s12958-018-0348-8. Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary

Liu Q, Wu C, Huang S, Wu Q, Zhou T, Liu X, Liu X, Hu X, Li L. Int J Mol Med. 2018 May;41(5):2609-2618. doi: 10.3892/ijmm.2018.3489. Epub 2018 Feb 13. Decreased hyperpolarization-activated cyclic nucleotide-gated channels are involved in bladder dy...

Tian X, Liu C, Wang X, Wang F, Wang L, Xu L, Ma J, Gao Y, Bao Y, Wang F, Sun L, Wei J, Lin C, Zhang H, Zhu G, Guan X, Fu S, Zhang C. Cell Death Dis. 2018 Mar 1;9(3):341. doi: 10.1038/s41419-018-0362-y. Sei-1 promotes double minute chromosomes form...

Cai XJ, Wang L, Hu CM. Biosci Rep. 2018 Jan 19;38(1). pii: BSR20171184. doi: 10.1042/BSR20171184. Print 2018 Feb 28. Effects of GABAB receptor activation on spatial cognitive function and hippocampal neurones in rat models of type 2 diabetes melli...

Ou, Z., Kong, X., Sun, X., He, X., Zhang, L., Gong, Z.,..., & Xuan, A. Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice. Brain, Behavior, and Immunity. Advance online publication. doi: 10.1016/j.bbi.2017...

Cheng, B., Zheng, H., Wu, F., Wu, J., Liu, X., Tang, C.,..., & Su, Z. (2017). Metabolomics analysis of Danggui Sini decoction on treatment of collagen-induced arthritis in rats. Journal of Chromatography B, 1061-1062, 282-291. doi: 10.1016/j.jchro...

Mei, F., Wang, J.G., Chen, Z.J., & Yuan, Z.L. (2017). Effects of epoxyeicosatrienoic acids (EETs) on retinal macular degeneration in rat models. European Review for Medical and Pharmacological Sciences, 21(12), 2970-2979. Retrieved from http://www...

Liu Q, Long Z, Dong X, Zhang T, Zhao J, Sun B, Zhu J, Li J, Wang Q, Yang Z, Hu X, Li L. Exp Mol Med. 2017 Apr 21;49(4):e319. doi: 10.1038/emm.2017.31. Cyclophosphamide-induced HCN1 channel upregulation in interstitial Cajal-like cells leads to bla...

Wang J, Yang Z, Wen J, Ma F, Wang F, Yu K, Tang M, Wu W, Dong Y, Cheng X, Nie C, Chen L. J Pharmacol Sci. 2014;126(3):198-207. Epub 2014 Oct 21. Sklb-M8 Induces Apoptosis Through The Akt/Mtor Signaling Pathway In Melanoma Models And Inhibits Angio...

Wang Q, Zhu J, Zou L, Yang Y. J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):246-50. Doi: 10.1007/S11596-011-0261-2. Epub 2011 Apr 20. Role Of Axonal Guidance Factor Netrin-1 In Human Placental Vascular Growth.

Zhao Jw, Gao Zl, Mei H, Li Yl, Wang Y. Am J Med Sci. 2011 Jun;341(6):460-8. Doi: 10.1097/Maj.0B013E31820865D5. Differentiation Of Human Mesenchymal Stem Cells: The Potential Mechanism For Estrogen-Induced Preferential Osteoblast Versus Adipocyte D...

Zhang P, Wu X, Hu C, Wang P, Li X. In Vitro Cell Dev Biol Anim. 2012 Jan;48(1):30-6. Doi: 10.1007/S11626-011-9471-Y. Epub 2011 Dec 17. Rho Kinase Inhibitor Y-27632 And Accutase Dramatically Increase Mouse Embryonic Stem Cell Derivation.

Sun Y, Chen S, Song G, Ren L, Wei L, Liu N, Zhang D, Lv X. Int J Mol Med. 2012 Sep;30(3):622-8. Doi: 10.3892/Ijmm.2012.1032. Epub 2012 Jun 14. Effect Of Visfatin On The Function Of Endothelial Progenitor Cells In High-Fat-Fed Obese Rat...

Wang Y, Li Jr, Sun Mx, Ni B, Huan C, Huang L, Li C, Fan Hj, Ren Xf, Mao X. Antiviral Res. 2014 Jun;106:33-41. Doi: 10.1016/J.Antiviral.2014.03.007. Epub 2014 Mar 25. Triggering Unfolded Protein Response By 2-Deoxy-D-Glucose Inhibits Porcine Epidem...

Liu C, Xia X, Miao W, Luan X, Sun L, Jin Y, Liu L. Int J Pharm. 2013 Oct 15;455(1-2):312-9. Doi: 10.1016/J.Ijpharm.2013.07.004. Epub 2013 Jul 15. An Ovarian Cell Microcapsule System Simulating Follicle Structure For Providing Endogenous Female Hor...

Jin F, Li L, Shi M, Li Z, Zhou J, Chen L. Behav Brain Res. 2013 Jun 1;246:116-24. Doi: 10.1016/J.Bbr.2013.02.029. Epub 2013 Mar 15. The Longitudinal Study Of Rat Hippocampus Influenced By Stress: Early Adverse Experience Enhances Hippocampal Vulne...

Chen F, Wang H, Xiang X, Yuan J, Chu W, Xue X, Zhu H, Ge H, Zou M, Feng H, Lin J. J Surg Res. 2014 Dec;192(2):298-304. Doi: 10.1016/J.Jss.2014.06.026. Epub 2014 Jun 19. Curcumin Increased The Differentiation Rate Of Neurons In Neural Stem Cells Vi...

Wang J, Ren Y, Guo X, Cheng H, Ye Y, Qi J, Yang C, You H. Mol Med Rep. 2015 May;11(5):3585-92. Doi: 10.3892/Mmr.2015.3164. Epub 2015 Jan 8. Alterations In Enhancer Of Zeste Homolog 2, Matrix Metalloproteinase-2 And Tissue Inhibitor Of Metalloprote...

Zhang R, Fang H, Chen Y, Shen J, Lu H, Zeng C, Ren J, Zeng H, Li Z, Chen S, Cai D, Zhao Q. Plos One. 2012;7(2):E32356. Doi: 10.1371/Journal.Pone.0032356. Epub 2012 Feb 27. Gene Expression Analyses Of Subchondral Bone In Early Experimental Osteoart...

Pang W, Zhang Y, Zhao N, Darwiche Ss, Fu X, Xiang W. Placenta. 2013 Jul;34(7):613-8. Doi: 10.1016/J.Placenta.2013.03.013. Epub 2013 Apr 17. Low Expression Of Mfn2 Is Associated With Mitochondrial Damage And Apoptosis In The Placental Villi Of Earl...

Peterson Am, Pilz-Allen C, Kolesnikova T, M??hwald H, Shchukin D. Acs Appl Mater Interfaces. 2014 Feb 12;6(3):1866-71. Doi: 10.1021/Am404849Y. Epub 2013 Dec 16. Growth Factor Release From Polyelectrolyte-Coated Titanium For Implant Applications.

Xing J, Jin H, Hou T, Chang Z, Luo F, Wang P, Li Z, Xie Z, Xu J. J Surg Res. 2014 Dec;192(2):454-63. Doi: 10.1016/J.Jss.2014.05.037. Epub 2014 May 27. Establishment Of A Bilateral Femoral Large Segmental Bone Defect Mouse Model Potentially Applica...

Ding Y, Yuan S, Liu X, Mao P, Zhao C, Huang Q, Zhang R, Fang Y, Song Q, Yuan D, Xie P, Liu Y, Liu Q. Plos One. 2014 Nov 20;9(11):E112207. Doi: 10.1371/Journal.Pone.0112207. Ecollection 2014. Protective Effects Of Astragaloside Iv On Db/Db Mice Wit...

Lv Y, Xia Jy, Chen Jy, Zhao H, Yan Hc, Yang Hs, Li Q, Fan Yx, Guo Kj, Chen Xy. Bmc Musculoskelet Disord. 2014 Nov 6;15:370. Doi: 10.1186/1471-2474-15-370. Effects Of Pamidronate Disodium On The Loss Of Osteoarthritic Subchondral Bone And The Expre...

Liang Gb, Luo Gh, Bao Ds, Chen Aj, Zhuang Yx, Guo Yn, Wang X, Wang Yl, Chen Zp, Lu Yp, Li Yp. Mol Med Rep. 2015 Aug;12(2):2577-83. Doi: 10.3892/Mmr.2015.3713. Epub 2015 May 4. Impact Of Immunosuppressive Agents On The Expression Of Indoleamine 2,3...

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Gu X, Fu J, Bai J, Zhang C, Wang J, Pan W. Am J Med Sci. 2015 Feb;349(2):157-61. Doi: 10.1097/Maj.0000000000000385. Low-Frequency Electrical Stimulation Induces The Proliferation And Differentiation Of Peripheral Blood Stem Cells Into Schwann Cells.

Wang J, Yin T, Wen Y, Tian F, He X, Zhou D, Lin Y, Yang J. Reprod Fertil Dev. 2015 Apr 15. Doi: 10.1071/Rd14499. [Epub Ahead Of Print] Potential Effects Of Interferon Regulatory Factor 4 In A Murine Model Of Polyinosinic-Polycytidylic Acid-Induced...

Wen L, Zhang C, Nong Y, Yao Q, Song Z. Cell Biochem Biophys. 2013 Jan;65(1):43-55. Doi: 10.1007/S12013-012-9402-X. Mild Electrical Pulse Current Stimulation Upregulates S100A4 And Promotes Cardiogenesis In Msc And Cardiac Myocytes Coculture Monola...

Lin Fs, Shen Sq, Chen Zb, Yan Rc. Shock. 2012 Feb;37(2):183-90. Doi: 10.1097/Shk.0B013E31823F1918. 17??-Estradiol Attenuates Reduced-Size Hepatic Ischemia/Reperfusion Injury By Inhibition Apoptosis Via Mitochondrial Pathway In Rats.

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15 Customer Q&As for 4% Paraformaldehyde (PFA) Solution in PBS

Question

Does AR1068 contain any methanol?

Verified customer

Asked: 2022-04-19

Answer

The 4% Paraformaldehyde (PFA) Solution In PBS (AR1068) is methanol free.

Boster Scientific Support

Answered: 2022-04-19

Question

Is this PFA solution is ready to be used for fixing. Or does it require any more preparations to be used for immunostaining?

Verified customer

Asked: 2022-02-28

Answer

This PFA solution is ready to be used for fixing.

Boster Scientific Support

Answered: 2022-02-28

Question

Can AR1068 be used for electron microscopy biological sample preparation?

Verified customer

Asked: 2020-10-19

Answer

The 4% Paraformaldehyde (PFA) Solution In PBS (AR1068) can not be used directly for electron microscopy. It could mix with other reagents such as glutaraldehyde to be used for electron microscopy.

Boster Scientific Support

Answered: 2020-10-20

Question

Do you think AR1068 is suitable to fix cells prior to analysis by Flow Cytometry?

Verified customer

Asked: 2020-06-29

Answer

The 4% Paraformaldehyde (PFA) Solution In PBS (AR1068) is suitable to fix cells prior to analysis by Flow Cytometry.

Boster Scientific Support

Answered: 2020-07-01

Question

How long can this product be stored after being opened at -20°C?

Verified Customer

Verified customer

Asked: 2020-04-29

Answer

Please use this product within the shelf life of one year at -20°C after the solution is opened

Boster Scientific Support

Answered: 2020-04-29

Question

is AR1068 0.2 um filtered?

Verified Customer

Verified customer

Asked: 2020-01-16

Answer

A

Boster Scientific Support

Answered: 2020-01-16

Question

Is the 4% PFA solution in PBS methanol free?

Verified Customer

Verified customer

Asked: 2019-11-14

Answer

Yes, it is methanol free.

Boster Scientific Support

Answered: 2019-11-14

Question

Can I dilute AR1068 from 4% to 1% Paraformaldehyde (PFA) solution in PBS? What is the protocol? Keywords: dilution, concentration

Verified Customer

Verified customer

Asked: 2019-11-08

Answer

Yes, the 4% Paraformaldehyde can be diluted to 1% in PBS. The dilution protocol is as follows: (1) Prepare the PBS by adding 14.2g Na2HPO4 and 9g NaCl into 1000ml H2O. (2) Mix 500mL 4% Paraformaldehyde with 1500mL PBS thoroughly.

Boster Scientific Support

Answered: 2019-11-08

Question

How pure (%) is the PFA in your pre-made solution?

Verified Customer

Verified customer

Asked: 2019-09-24

Answer

Purity of the solid formaldehyde is ≥95%.

Boster Scientific Support

Answered: 2019-09-24

Question

Is AR1068 PFA solution DepC RNAse free?

Verified customer

Asked: 2019-07-12

Answer

Our 4% Paraformaldehyde (PFA) Solution In PBS (AR1068) contains DepC RNAse.

Boster Scientific Support

Answered: 2019-07-12

Question

Since we will be using this on a daily basis, should it be stored at room temperature or at 4°C? What is the shelf life for these conditions?

Verified Customer

Verified customer

Asked: 2018-12-14

Answer

Please store the product at 4°C if it is frequently used. The shelf life is 3 months at 4°C. For long storage, please store at -20°C.

Boster Scientific Support

Answered: 2018-12-14

Question

What is the PBS concentration?

Verified Customer

Verified customer

Asked: 2017-10-06

Answer

PBS concentration is 0.01g/mL.

Boster Scientific Support

Answered: 2017-10-06

Question

What is the detailed composition of AR1068?

Verified Customer

Verified customer

Asked: 2017-05-08

Answer

AR1068 contains paraformaldehyde, Na2HPO4, NaCl, and DEPC.

Boster Scientific Support

Answered: 2017-05-08

Question

Is this product DNA/RNA free?

Verified Customer

Verified customer

Asked: 2015-11-09

Answer

Yes, AR1068 is DNA/RNA free.

Boster Scientific Support

Answered: 2015-11-09

Question

We will use this to fix bacterial cells from faecal samples. Do you have any reference for this use?

Verified Customer

Verified customer

Asked: 2014-12-26

Answer

We haven't use AR1068 to fix bacterial cells from faecal samples. We could not provide any reference for this use. We're sorry for the inconvenience.

Boster Scientific Support

Answered: 2014-12-26

Total: $60

SKU:AR1068

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