Anti-Activin receptor type-1B ACVR1B Antibody

Product Name

Anti-Activin receptor type-1B ACVR1B Antibody

View all ACVR1B Antibodies

SKU/Catalog Number

A02882

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Activin receptor type-1B ACVR1B Antibody (Catalog # A02882). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

ACVR1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Activin receptor type-1B ACVR1B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02882)

Host

Rabbit

Contents

ACVR1B Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

ACVR1B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ACVR1B. The immunogen is located within amino acids 140 - 190 of ACVR1B.

Cross-reactivity

At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.

Reactive Species

A02882 is reactive to ACVR1B in Human, Mouse

Observed Molecular Weight

68 kDa

Calculated molecular weight

56.8 kDa

Background of ACVR1B

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A02882 is guaranteed for ELISA, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ACVR1B antibody can be used for detection of ACVR1B by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information ACVR1B

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