Anti-Activin receptor type-1B ACVR1B Antibody

Activin RIB/ALK-4 antibody

Boster Bio Anti-Activin receptor type-1B ACVR1B Antibody (Catalog # A02882). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Info Summary

SKU: A02882
Size: 0.1 mg
Reactive Species: Human, Mouse
Host: Rabbit
Application: ELISA, WB

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Product Name

Anti-Activin receptor type-1B ACVR1B Antibody

View all Activin RIB/ALK-4 Antibodies

SKU/Catalog Number

A02882

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Activin receptor type-1B ACVR1B Antibody (Catalog # A02882). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

ACVR1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Activin receptor type-1B ACVR1B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02882)

Host

Rabbit

Contents

ACVR1B Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

ACVR1B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ACVR1B. The immunogen is located within amino acids 140 - 190 of ACVR1B.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.

Reactive Species

A02882 is reactive to ACVR1B in Human, Mouse

Applications

A02882 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

56.807kDa

Background of Activin RIB/ALK-4

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ACVR1B antibody can be used for detection of ACVR1B by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For ACVR1B (Source: Uniprot.org, NCBI)

Gene Name

ACVR1B

Full Name

Activin receptor type-1B

Weight

56.807kDa

Superfamily

protein kinase superfamily

Alternative Names

activin A receptor, type IB; Activin receptor type IB; Activin receptor-like kinase 4; Activin RIB; ActivinRIB; ACTRIB; ACVR1B; ACVRLK4ACTR-IB; ALK4; ALK-4; ALK4activin A receptor, type II-like kinase 4; EC 2.7.11; EC 2.7.11.30; Serine/threonine-protein kinase receptor R2; SKR2activin receptor type-1B ACVR1B ACTRIB, ACVRLK4, ALK4, SKR2 activin A receptor type 1B activin receptor type-1B|activin A receptor, type IB|activin A receptor, type II-like kinase 4|activin receptor-like kinase 4|serine/threonine-protein kinase receptor R2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ACVR1B, check out the ACVR1B Infographic

ACVR1B infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ACVR1B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Size

Total: $449

SKU:A02882

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Lead time for this item is typically 4-7 days

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A02882
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$449.00

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