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Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a main activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and triggers its serine- threonine kinase.
|protein kinase superfamily|
|Sequence:||12; NC_000012.12 (51951696..51997079)|
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Cell membrane; Single-pass type I membrane protein.