Activin receptor type-1B (ACVR1B)

Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes such as neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.

Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a main activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and triggers its serine- threonine kinase.