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- Table of Contents
Activin receptor type-1B Antibodies
AND ACVR1B ELISA kits, Activin receptor type-1B Proteins
Many biological assays use antibodies to detect Activin receptor type-1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Activin receptor type-1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Activin receptor type-1B antibodies...
Designing a Western blot for Activin receptor type-1B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ACVR1B Western Blot GuideACVR1B Infographic by Boster Bio
All ACVR1B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02882
100 μl/vial
Cat # M02882
100 μl/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1716
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1716
1 kit, containing one 96-well plate and all necessary reagents
ACVR1B Overview
Facts about Activin receptor type-1B.
Activin receptor type-1B (ACVR1B)
Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes such as neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.
Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a main activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and triggers its serine- threonine kinase.
Gene Information
| Human | |
|---|---|
| Gene Name: | ACVR1B |
| Uniprot: | P36896 |
| Entrez: | 91 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
activin A receptor, type IB; Activin receptor type IB; Activin receptor-like kinase 4; Activin RIB; ActivinRIB; ACTRIB; ACVR1B; ACVRLK4ACTR-IB; ALK4; ALK-4; ALK4activin A receptor, type II-like kinase 4; EC 2.7.11; EC 2.7.11.30; Serine/threonine-protein kinase receptor R2; SKR2activin receptor type-1B
Molecular Weight
Mass (kDA):
56.807 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (51951696..51997079) |
Tissue Specificity
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Pituitary Diseases
- Cardio-facio-cutaneous Syndrome
- Adenocarcinoma
- Cell Transformation, Neoplastic
- Fibrosis
- Cell Invasion
- Melanoma
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Chimera Disorder
- Metaplastic Cell Transformation
Interacting Proteins
- Acvr2b
- FKBP1A
- HSP90AB1
- SMAD7
Pathways
- Gastrulation
- Cell Growth
- Cell Proliferation
- Secretion
- Cell Migration
- Mesoderm Formation
- Pathogenesis
- Oncogenesis
- Nodal Signaling Pathway
- Cell Cycle
- Axis Specification
- Rna Interference
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACVR1B
bosterbio.com/bosterbio-gene-info-cards/ACVR1B
References
PMID: 8397373 by ten Dijke P., et al. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
PMID: 8196624 by Carcamo J., et al. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.