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- Table of Contents
Facts about Activin receptor type-1B.
Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a main activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and triggers its serine- threonine kinase.
Human | |
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Gene Name: | ACVR1B |
Uniprot: | P36896 |
Entrez: | 91 |
Belongs to: |
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protein kinase superfamily |
activin A receptor, type IB; Activin receptor type IB; Activin receptor-like kinase 4; Activin RIB; ActivinRIB; ACTRIB; ACVR1B; ACVRLK4ACTR-IB; ALK4; ALK-4; ALK4activin A receptor, type II-like kinase 4; EC 2.7.11; EC 2.7.11.30; Serine/threonine-protein kinase receptor R2; SKR2activin receptor type-1B
Mass (kDA):
56.807 kDA
Human | |
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Location: | 12q13.13 |
Sequence: | 12; NC_000012.12 (51951696..51997079) |
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Cell membrane; Single-pass type I membrane protein.
PMID: 8397373 by ten Dijke P., et al. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
PMID: 8196624 by Carcamo J., et al. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.