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- Table of Contents
BARD1 Antibodies
AND BARD1 ELISA kits, BARD1 Proteins
Many biological assays use antibodies to detect BARD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BARD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BARD1 antibodies...
Designing a Western blot for BARD1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BARD1 Western Blot GuideBARD1 Infographic by Boster Bio
All BARD1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01646-2
100 μg/vial
Cat # A01646-2
100 μg/vial
BARD1 Overview
Facts about BRCA1-associated RING domain protein 1.
BRCA1-associated RING domain protein 1 (BARD1)
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of'Lys-6'-linked polyubiquitin chains and coordinates a wide range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability.
Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that's required for its tumor suppressor function.
Gene Information
| Human | |
|---|---|
| Gene Name: | BARD1 |
| Uniprot: | Q99728 |
| Entrez: | 580 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BARD-1; BRCA1 associated RING domain 1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; EC 6.3.2.-
Molecular Weight
Mass (kDA):
86.648 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q35 |
| Sequence: | 2; NC_000002.12 (214725645..214809683, complement) |
Subcellular Localizations
Nucleus. During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
- Carcinoma
- Genotoxic Stress
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Genomic Instability
- Carcinogenesis
- Sporadic Breast Carcinoma
Interacting Proteins
- BRCA1
- CEP126
- CEP70
- CHD3
- CSTF1
- CSTF2
- EXOC5
- FAM9B
- GIT1
- GOLGA2
Pathways
- Dna Repair
- Cell Cycle
- Localization
- S Phase
- Nuclear Export
- Cell Cycle Checkpoint
- Dna Replication
- Mitosis
- Proteolysis
- Cell Proliferation
- Cell Death
- Double-strand Break Repair
- Cell Growth
PTMs
- Ubiquitination
- Phosphorylation
- Cleavage
Research Areas
- Breast Cancer
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BARD1
bosterbio.com/bosterbio-gene-info-cards/BARD1
References
PMID: 8944023 by Wu L.C., et al. Identification of a RING protein that can interact in vivo with the BRCA1 gene product.
PMID: 9425226 by Thai T.H., et al. Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.