Anti-CALHM1 Antibody

Product Name

Anti-CALHM1 Antibody

View all CALHM1 Antibodies

SKU/Catalog Number

A03599-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-CALHM1 Antibody (Catalog # A03599-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

CALHM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-CALHM1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03599-1)

Host

Rabbit

Contents

CALHM1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

CALHM1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1. The immunogen is located within amino acids 60 - 110 of CALHM1.

Reactive Species

A03599-1 is reactive to CALHM1 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

38.3 kDa

Background of CALHM1

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A03599-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

CALHM1 antibody can be used for detection of CALHM1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information CALHM1

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