|Ig Isotype||Mouse IgG1|
|Product Name||Anti-Calmodulin Antibody (Monoclonal, 6D4)|
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Mouse IgG monoclonal antibody for Calmodulin, calmodulin 1; calmodulin 2; calmodulin 3 (CALM1; CALM2; CALM3) detection. Tested with WB in chicken;rat. No cross reactivity with other proteins.|
|Cite This Product||Anti-Calmodulin Antibody (Monoclonal, 6D4) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1010)|
|Immunogen||Preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.|
Assay Dilutions Overview
Boster's Secondary Antibodies And IHC, WB Kits
The following reagents are used to generate the images below.Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot.
Protein Target Info (Source: Uniprot.org)
|Alternative Names||Calmodulin;CaM;Calm1;Calm, Cam, Cam1;Calm2;Cam2, Camb;Calm3;Cam3, Camc;|
|Subcellular Localization||Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. .|
|Molecular Weight||16838 MW|
*if product is indicated to react with multiple species, protein info is based on the human gene.
|Protein Function||Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). .|
|Background||Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. Three calmodulin genes(CALM1, CALM2, and CALM3) map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively.|
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