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- Table of Contents
CD207 Antibodies
AND CD207 ELISA kits, CD207 Proteins
Many biological assays use antibodies to detect CD207, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD207 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD207 antibodies...
Designing an IHC experiment for CD207? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CD207 IHC GuideCD207 Infographic by Boster Bio
All CD207 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK2162
96 wells/kit, with removable strips.
Cat # EK2162
96 wells/kit, with removable strips.
CD207 Overview
Facts about C-type lectin domain family 4 member K.
C-type lectin domain family 4 member K (CD207)
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a powerful regulator of membrane superimposition and zippering.
Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | CD207 |
| Uniprot: | Q9UJ71 |
| Entrez: | 50489 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD207 antigen; CD207 antigen, langerin; CD207 molecule, langerin; CD207; CLEC4KLangerhans cell specific c-type lectin; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; Langerin
Molecular Weight
Mass (kDA):
36.725 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p13.3 |
| Sequence: | 2; NC_000002.12 (70825248..70860787, complement) |
Tissue Specificity
Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Subcellular Localizations
Membrane; Single-pass type II membrane protein. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Diseases
- Neoplasms
- Histiocytosis, Langerhans-cell
- Inflammation
- Histiocytosis
- Hiv Infections
- Diphtheria
- Contact Dermatitis
- Contact Hypersensitivity
- Carcinoma
- Malignant Neoplasms
- Malignant Paraganglionic Neoplasm
- Infective Disorder
Interacting Proteins
- GRAMD2B
Pathways
- Immune Response
- Pathogenesis
- Hypersensitivity
- Localization
- Transport
- Cell Activation
- Endocytosis
- Sensitization
- Cell Differentiation
- Adaptive Immune Response
- Secretion
- Cytokine Production
- Cell Adhesion
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD207
bosterbio.com/bosterbio-gene-info-cards/CD207
References
PMID: 10661407 by Valladeau J., et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
PMID: 12626394 by Stambach N.S., et al. Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells.