Thimet oligopeptidase Antibodies

AND THOP1 ELISA kits, Thimet oligopeptidase Proteins

Many biological assays use antibodies to detect Thimet oligopeptidase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Thimet oligopeptidase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Thimet oligopeptidase antibodies...

We validate the specificity of these antibodies to Thimet oligopeptidase by testing them on tissues known to express THOP1 positively and negatively. Browse below to find the THOP1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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THOP1 Infographic by Boster Bio

All THOP1 Products

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Anti-Thimet oligopeptidase THOP1 Antibody

Western blot analysis of extracts of various cell lines, using THOP1 antibody at 1:1000 dilution

Human, Mouse, Rat

$405
Cat # A08010
100ul

Thimet Oligopeptidase (THOP1) (NM_003249) Human Recombinant Protein

Coomassie blue staining of purified THOP1 protein

$1062
Cat # PROTP52888
20 µg

Anti-Thimet Oligopeptidase (THOP1) Mouse Monoclonal Antibody [Clone ID: OTI2D3]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY THOP1 (Right lane) cDNA for 48 hrs and lysed

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-THOP1 mouse monoclonal antibody

Equivalent amounts of cell lysates (10 ug per lane) of wild-type HEK293T cells (WT) and THOP1-Knockout HEK293T cells (KO) were separated by SDS-PAGE and immunoblotted with anti-THOP1 monoclonal antibody M08010 (1:500)

Human, Mouse, Rat

IHC, WB

$523
Cat # M08010
100 µl

Thimet Oligopeptidase (THOP1) (NM_003249) Human Over-expression Lysate

Human

$628
Cat # LS007064
20 µg, 100 µg

THOP1 Overview

Facts about Thimet oligopeptidase.

THOP1 3D structure. Source: alphafold

Thimet oligopeptidase (THOP1)

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation.

Able to degrade the amyloid-beta precursor protein and create amyloidogenic fragments. .

Gene Information

Human
Gene Name:	THOP1
Uniprot:	P52888
Entrez:	7064

Family

Belongs to:

peptidase M3 family

Alternative Names

EC 3.4.24; EC 3.4.24.15; Endopeptidase 24.15; EP24.15; MEPD_HUMAN; MP78; thimet oligopeptidase 1; thimet oligopeptidase; THOP1; TOP

Molecular Weight

Mass (kDA):
78.84 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (2785466..2815807)

Subcellular Localizations

Cytoplasm.

Diseases

Alzheimer's Disease
Infarction
Heart Failure
Cardiac Hypertrophy
Chronic Eosinophilic Leukemia
Diabetic Cardiomyopathies
Myocardial Infarction
Cardiomyopathies
Malignant Neoplasms
Hypertrophy

Diabetes Mellitus, Experimental
Dental Plaque
Alzheimer Disease, Familial
Plaque, Amyloid

Pathways

Localization
Coagulation
Cell Cycle
Fertilization
Metaphase
Pathogenesis

PTMs

Acetylation

Phosphoprotein

Research Areas

Alzheimers Research
Lipid and Metabolism
Neurodegeneration
Neuronal Cell Markers
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/THOP1

References

PMID: 7639763 by Thompson A., et al. Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide.

PMID: 8286339 by Papastoitsis G., et al. Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.