Product Info Summary
SKU: | A09950-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC |
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Product info
Product Name
Anti-Cerebral 1 (L310) RRP8 Antibody
SKU/Catalog Number
A09950-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Cerebral 1 (L310) RRP8 Antibody catalog # A09950-1. Tested in IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Cerebral 1 (L310) RRP8 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09950-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human HUCE1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A09950-1 is reactive to RRP8 in Human, Mouse, Rat
Applications
A09950-1 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
50.715kDa
Background of HUCE1
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Yazaki M., Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Ishikawa K., DNA Res. 4:307-313(1997).
The MGC Project Team; Genome Res. 14:2121-2127(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of RRP8 using Anti-Cerebral 1 (L310) RRP8 Antibody (A09950-1).
Immunohistochemistry (IHC) analyzes of Cerebral 1 (L310) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.For more protocol information of IHC
Protein Target Info & Infographic
Gene/Protein Information For RRP8 (Source: Uniprot.org, NCBI)
Gene Name
RRP8
Full Name
Ribosomal RNA-processing protein 8
Weight
50.715kDa
Superfamily
methyltransferase superfamily
Alternative Names
Cerebral protein 1; KIAA0409EC 2.1.1.-; NML; nucleomethylin; ribosomal RNA processing 8, methyltransferase, homolog (yeast); ribosomal RNA-processing protein 8; RRP8 methyltransferase homolog RRP8 KIAA0409, NML ribosomal RNA processing 8 ribosomal RNA-processing protein 8|RRP8 methyltransferase homolog|cerebral protein 1|nucleomethylin|ribosomal RNA processing 8, methyltransferase, homolog
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on RRP8, check out the RRP8 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for RRP8: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cerebral 1 (L310) RRP8 Antibody (A09950-1)
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No publications found for A09950-1
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