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Boster Bio Anti-CXCR4 Antibody catalog # PA1237. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 17 publication(s).
|Reactivity:||Human, Mouse, Rat|
|Conjugation:||Choose a conjugate option when adding to cart. Sample size cannot be ordered with conjugation. Conjugated antibody size will be reduced in half due to loss in the conjugation process.|
|Product Name||Anti-CXCR4 Antibody
See more CXCR4 products
|Storage & Handling||Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.|
|Description||Boster Bio Anti-CXCR4 Antibody catalog # PA1237. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.|
|Cite This Product||Anti-CXCR4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1237)|
|Antibodies Validation||Antibodies Validation Information|
|Similar Products From
|Anti-CXCR4 Antibody may replace the following items: sc 12764|sc 366006|sc 376270|sc 398601|sc 53534|sc 6190|sc 6191|sc 6279|sc 82958|sc 82959|sc 82960|sc 9046.|
|Reactive Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $100. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4 (18-33aa SGDYDSMKEPCFREEN), different from the related rat and mouse sequences by two amino acids.|
|Cross Reactivity||No cross reactivity with other proteins|
|NCBI Gene Id||7852|
|Species Of This Entry||Human|
|Protein Name||C-X-C chemokine receptor type 4|
|Superfamily||G-protein coupled receptor 1 family|
|Alternative Names||CXCR4|CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201E; D2S201ESDF-1 receptor; FB22; Fusin; HM89; HM89NPYRL; HSY3RR; LAP3; LAP-3; LCR1; LESTR; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3R; NPY3RWHIM; NPYR; NPYRL; NPYY3R; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor;|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Want a nice infographic on your next protein? Boster's got them all. All proteins in the human genome, and some, can be found in the Boster Bio gene infographics. Download it and share it with your colleagues and friends. Big size posters available upon request.
In this infographic you will see the following information for CXCR4: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. Some times it even contains some opt-ed articles the Boster team on the scientific news and clinical impacts of this protein, though not all have that. Too many proteins, you know.
Our Boster Quality Guarantee for Anti-CXCR4 Antibody covers its use in the following applications.Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
Here are featured tools and databases that you might find useful.
|Liu Y,Feng Q,Miao J,Wu Q,Zhou S,Shen W,Feng Y,Hou FF,Liu Y,Zhou L.C-X-C motif chemokine receptor 4 aggravates renal fibrosis through activating JAK/STAT/GSK3β/β-catenin pathway.J Cell Mol Med.2020 Apr;24(7):3837-3855.doi:10.1111/jcmm.14973.Epub 2020 Mar 2.PMID:32119183;PMCID:PMC7171406.
PA1237 usage in article: APP:IHC, SAMPLE:KIDNEY TISSUE, DILUTION:NA
|PubMed ID 32119183|
|Gao W,Yang X,Du J,Wang H,Zhong H,Jiang J,Yang C.Glucocorticoid guides mobilization of bone marrow stem/progenitor cells via FPR and CXCR4 coupling.Stem Cell Res Ther.2021 Jan 7;12(1):16.doi:10.1186/s13287-020-02071-1.PMID:33413641;PMCID:PMC7791823.
PA1237 usage in article: APP:IF, SAMPLE:MSCS AND EPCS, DILUTION:NA
|PubMed ID 33413641|
|Macrophage migration inhibitory factor%u2013CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors||PubMed ID 25712213|
|CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4%u2011activated MEK/ERK and PI3K/AKT pathways||PubMed ID 30221695|
|Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer||PubMed ID 18983683|
|Blockade of CXCL12/CXCR4 signaling inhibits intrahepatic cholangiocarcinoma progression and metastasis via inactivation of canonical Wnt pathway||PubMed ID 25471741|
|Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF-1? expression?in vivo||PubMed ID 24912495|
|Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer||PubMed ID 2596092|
|Wang J, Cai J, Han F, Yang C, Tong Q, Cao T, Wu L, Wang Z. Int J Gynecol Cancer. 2011 Aug;21(6):981-7. Doi: 10.1097/Igc.0B013E31821D2543. Silencing Of Cxcr4 Blocks Progression Of Ovarian Cancer And Depresses Canonical Wnt Signaling Pathway.||PubMed ID 21738044|
|Li Y, Chen M, Yuan J, Zhou X, He W, Zu X, Qi L. Urol Int. 2014;92(2):157-63. Doi: 10.1159/000351952. Epub 2013 Aug 27. Cxcr4 Expression In Bladder Transitional Cell Carcinoma And Its Relationship With Clinicopathological Features.||PubMed ID 23988662|
|Tan Xy, Chang S, Liu W, Tang Hh. Gut Liver. 2014 Mar;8(2):196-204. Doi: 10.5009/Gnl.2014.8.2.196. Epub 2013 Nov 5. Silencing Of Cxcr4 Inhibits Tumor Cell Proliferation And Neural Invasion In Human Hilar Cholangiocarcinoma.||PubMed ID 24672662|
|Li S, Deng L, Gong L, Bian H, Dai Y, Wang Y. Neurosci Res. 2010 Aug;67(4):293-9. Doi: 10.1016/J.Neures.2010.04.006. Epub 2010 Apr 20. Upregulation Of Cxcr4 Favoring Neural-Like Cells Migration Via Akt Activation.||PubMed ID 20412823|
|Lin F, Zheng Se, Shen Z, Tang Ln, Chen P, Sun Yj, Zhao H, Yao Y. Med Oncol. 2011 Jun;28(2):649-53. Doi: 10.1007/S12032-010-9493-4. Epub 2010 Mar 27. Relationships Between Levels Of Cxcr4 And Vegf And Blood-Borne Metastasis And Survival In Patients...||PubMed ID 20349215|
|Chen Hy, Wang Jm, Wang Hy, Zhang Yx, Liu W, Pan L, Wang Wh, Chen Sf, Jin Wg, Wang L. Biomed Pharmacother. 2012 Oct;66(7):549-53. Doi: 10.1016/J.Biopha.2012.04.007. Epub 2012 May 24. Effect Of Short Hairpin Rna-Induced Cxcr4 Silence On Ovarian Canc...||PubMed ID 22902648|
|Wang D, Guo S, Han Sy, Xu N, Guo Jy, Sun Q. Int J Oncol. 2013 May;42(5):1725-33. Doi: 10.3892/Ijo.2013.1841. Epub 2013 Feb 27. Distinct Roles Of Different Fragments Of Pdcd4 In Regulating The Metastatic Behavior Of B16 Melanoma Cells.||PubMed ID 23450345|
|Zhang W, Wang X, Yue K, Liu S, Liu X. Biomed Res Int. 2015;2015:195828. Doi: 10.1155/2015/195828. Epub 2015 Mar 19. Construction Of A Cxcl12-Kdel Fusion Gene To Inhibit Head And Neck Squamous Cell Carcinoma Metastasis By Intracellular Sequestratio...||PubMed ID 25866764|
|Liu W, Wang Y, Wang H, Wang A. Cell Biochem Biophys. 2014 Dec;70(3):1893-900. Doi: 10.1007/S12013-014-0148-5. Anticancer Effects Of Chemokine Receptor 4(Cxcr4) Gene Silenced By Cxcr4-Sirna In Nude Mice Model Of Ovarian Cancer.||PubMed ID 25149650|
Domestically in USA and Canada, ships next business day if available in stock.
Note: sample size takes longer to process, average 5-7 days.
For a full list of fitting secondary antibodies, conjugated with all common conjugates for WB and IHC applications, click the link below.All secondary antibodies
To order the blocking peptide or the immungen protein ($99 / 1mg) for Anti-CXCR4 Antibody PA1237, contact [email protected] for a quote. Or use the live chat function.
Did you know Boster offer custom antibody production service? You can have your antibodies custom made for as low as $600 if your research fit one of these 3 criteria:
Comprehensive info on CXCR4, beautifully presented.Open Infographic
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