Product Info Summary
SKU: | A03388 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-E3 SUMO-protein ligase CBX4 CBX4 Antibody
SKU/Catalog Number
A03388
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-E3 SUMO-protein ligase CBX4 CBX4 Antibody (Catalog # A03388). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CBX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-E3 SUMO-protein ligase CBX4 CBX4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03388)
Host
Rabbit
Contents
CBX4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
SK7
Isotype
IgG
Immunogen
CBX4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CBX4. The immunogen is located within amino acids 50 - 100 of CBX4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Two alternatively spliced transcript variants have been observed.
Reactive Species
A03388 is reactive to CBX4 in Human, Mouse, Rat
Applications
A03388 is guaranteed for ELISA, IF, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
61.368kDa
Background of CBX4
Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CBX4 antibody can be used for detection of CBX4 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Click image to see more details
Immunofluorescence of CBX4 in human brain tissue with CBX4 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CBX4 (Source: Uniprot.org, NCBI)
Gene Name
CBX4
Full Name
E3 SUMO-protein ligase CBX4
Weight
61.368kDa
Alternative Names
chromobox homolog 4 (Drosophila Pc class); chromobox homolog 4; Chromobox protein homolog 4; Drosophila); E3 SUMO-protein ligase CBX4; hPC2; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; Polycomb 2 homolog CBX4 NBP16, PC2 chromobox 4 E3 SUMO-protein ligase CBX4|NS5ATP1-binding protein 16|Pc class 2 homolog|chromobox homolog 4 (Pc class homolog, Drosophila)|chromobox protein homolog 4|chromobox-like protein 4|polycomb 2 homolog
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CBX4, check out the CBX4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CBX4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-E3 SUMO-protein ligase CBX4 CBX4 Antibody (A03388)
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No publications found for A03388
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