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Product Info Summary
| SKU: | A00714-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Emerin EMD Antibody
SKU/Catalog Number
A00714-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Emerin EMD Antibody (Catalog # A00714-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Emerin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Emerin EMD Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00714-1)
Host
Rabbit
Contents
Emerin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Emerin antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human Emerin. The immunogen is located within the first 50 amino acids of Emerin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This Mcl-1 antibody detects isoforms Mcl-1L and Mcl-1ES.
Reactive Species
A00714-1 is reactive to EMD in Human, Mouse, Rat
Applications
A00714-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
28.994kDa
Background of Emerin
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family that includes proteins such as LAP2 and MAN1. Each family member, including Emerin, has an ~40 amino acid LEM-domains that binds barrier-to-autointegration (BANF1), a conserved chromatin protein that also serves as a host cell component of retroviral integration complexes, including that of HIV. Emerin is anchored at the inner membrane of the nuclear envelope where it binds to nuclear intermediate filaments that are formed by lamin proteins. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Emerin antibody can be used for detection of Emerin by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Emerin in human skeletal muscle tissue lysate with Emerin antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of emerin in human skeletal muscle tissue with emerin antibody at 2.5 μg/mL.
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Immunofluorescence of Emerin in Human Skeletal Muscle cells with Emerin antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For EMD (Source: Uniprot.org, NCBI)
Gene Name
EMD
Full Name
Emerin
Weight
28.994kDa
Alternative Names
emerin; Emery-Dreifuss muscular dystrophy; LEM domain containing 5; STAEDMDLEMD5 EMD EDMD, LEMD5, STA emerin emerin|LEM domain containing 5
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on EMD, check out the EMD Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for EMD: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Emerin EMD Antibody (A00714-1)
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