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- Table of Contents
Emerin Antibodies
AND EMD ELISA kits, Emerin Proteins
Many biological assays use antibodies to detect Emerin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Emerin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Emerin antibodies...
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EMD Infographic by Boster Bio
All EMD Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00714
100 μg/vial
Cat # A00714
100 μg/vial
Anti-Emerin EMD Antibody Picoband® (monoclonal, 5A10)
1 Citations 5 Q&As
Human
Flow Cytometry, IHC, ICC, WB
$370
Cat # M00714
100 μg/vial
Cat # M00714
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00714-1
100 μl
Cat # M00714-1
100 μl
EMD Overview
Facts about Emerin.
Emerin (EMD)
Stabilizes and promotes the creation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments.
Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by changing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | EMD |
| Uniprot: | P50402 |
| Entrez: | 2010 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
emerin; Emery-Dreifuss muscular dystrophy; LEM domain containing 5; STAEDMDLEMD5
Molecular Weight
Mass (kDA):
28.994 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq28 |
| Sequence: | X; NC_000023.11 (154379236..154381523) |
Tissue Specificity
Skeletal muscle, heart, colon, testis, ovary and pancreas.
Subcellular Localizations
Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
Diseases
- Alveolar Bone Loss
- Gingival Recession
- Periodontal Attachment Loss
- Periodontal Pocket
- Periodontitis
- Neoplasms
- Cardiac Arrest
- Hemorrhage
- Chronic Periodontitis
- Dental Plaque
- Malignant Neoplasms
- Pain
- Electromechanical Dissociation
Interacting Proteins
- ABT1
- ACTB
- AEN
- BANF1
- BCLAF1
- BYSL
- CATSPER1
- CCDC155
- CEP70
- CTNNB1
Pathways
- Regeneration
- Tissue Regeneration
- Wound Healing
- Cell Proliferation
- Transport
- Secretion
- Sensitization
- Angiogenesis
- Cell Growth
- Localization
- Cell Differentiation
- Cell Adhesion
- Reflex
PTMs
- Phosphorylation
- Cleavage
- Reduction
- Oxidation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EMD
bosterbio.com/bosterbio-gene-info-cards/EMD
References
PMID: 7894480 by Bione S., et al. Identification of a novel X-linked gene responsible for Emery- Dreifuss muscular dystrophy.
PMID: 8733135 by Chen E.Y., et al. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.