Anti-FMRP FMR1 Antibody

FMRP antibody

Boster Bio Anti-FMRP FMR1 Antibody catalog # A00192-1. Tested in WB,ICC/IF,IHC applications. This antibody reacts with Human,Mouse,Rat.

Product Info Summary

SKU: A00192-1
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IF, IHC, ICC, WB

Product Name

Anti-FMRP FMR1 Antibody

View all FMRP Antibodies

SKU/Catalog Number

A00192-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-FMRP FMR1 Antibody catalog # A00192-1. Tested in WB,ICC/IF,IHC applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-FMRP FMR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00192-1)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human Flt-3 around the phosphorylation site of Y969.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A00192-1 is reactive to FMR1 in Human, Mouse, Rat

Applications

A00192-1 is guaranteed for IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

71.174kDa

Background of FMRP

FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Sekine S et,al. (2008) J Immunol. ;180(12):8126-34
Pratz K et,al. (2008) Leuk Lymphoma. 2008 ;49(5):852-63.
Al Shaer L et,al. (2008) Br J Haematol. 141(4):483-93.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:5,000-1:10,000

ICC: 1:100-1:500
IHC: 1:50-1:200

Validation Images & Assay Conditions

Gene/Protein Information For FMR1 (Source: Uniprot.org, NCBI)

Gene Name

FMR1

Full Name

Synaptic functional regulator FMR1

Weight

71.174kDa

Superfamily

FMR1 family

Alternative Names

FMRPFRAXAPOF; fragile X mental retardation 1 protein; fragile X mental retardation 1; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1 FMR1 FMRP, FRAXA, POF, POF1 FMRP translational regulator 1 synaptic functional regulator FMR1|fragile X mental retardation 1|fragile X mental retardation protein 1|truncated FMRP

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on FMR1, check out the FMR1 Infographic

FMR1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for FMR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A00192-1-100ul

100ul

$405

Free Secondary Antibody

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A00192-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$405.00

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