Anti-FXR1 Antibody

FXR1 antibody

Boster Bio Anti-FXR1 Antibody catalog # A03308. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.

Product Info Summary

SKU: A03308
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

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Product Name

Anti-FXR1 Antibody

View all FXR1 Antibodies

SKU/Catalog Number

A03308

Size

100ul

Form

Liquid

Description

Boster Bio Anti-FXR1 Antibody catalog # A03308. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-FXR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03308)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human COLQ

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03308 is reactive to FXR1 in Human, Mouse, Rat

Applications

A03308 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

69.721kDa

Background of FXR1

Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis, particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, and the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca2+ and promote a contractile state. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, its association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B.

Kawai T., Mol. Cell. Biol. 18:1642-1651(1998).
Murata-Hori M., FEBS Lett. 451:81-84(1999).
The MGC Project Team; Genome Res. 14:2121-2127(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000

Validation Images & Assay Conditions

Gene/Protein Information For FXR1 (Source: Uniprot.org, NCBI)

Gene Name

FXR1

Full Name

Fragile X mental retardation syndrome-related protein 1

Weight

69.721kDa

Superfamily

FMR1 family

Alternative Names

fragile X mental retardation syndrome-related protein 1; fragile X mental retardation, autosomal homolog 1; FXR1P; hFXR1p FXR1 FXR1P, MYOPMIL, MYORIBF FMR1 autosomal homolog 1 fragile X mental retardation syndrome-related protein 1|fragile X mental retardation, autosomal homolog 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on FXR1, check out the FXR1 Infographic

FXR1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for FXR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A03308-100ul

100ul

$405

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