Anti-Gelsolin/GSN Antibody Picoband™

Gelsolin/GSN antibody

Boster Bio Anti-Gelsolin/GSN Antibody Picoband™ catalog # PB9209. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. Cited in 3 publication(s).

Product Info Summary

SKU: PB9209
Size: 100 μg/vial
Reactive Species: Human, Monkey, Mouse, Rat
Host: Rabbit
Application: Flow Cytometry, IF, IHC, ICC, WB

Product Name

Anti-Gelsolin/GSN Antibody Picoband™

View all Gelsolin/GSN Antibodies

SKU/Catalog Number

PB9209

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Gelsolin/GSN Antibody Picoband™ catalog # PB9209. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Gelsolin/GSN Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9209)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human Gelsolin recombinant protein (Position: E580-A782). Human Gelsolin shares 94% and 95% amino acid (aa) sequences identity with mouse and rat Gelsolin, respectively.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9209 is reactive to GSN in Human, Monkey, Mouse, Rat

Applications

PB9209 is guaranteed for Flow Cytometry, IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

86 kDa

Calculated molecular weight

85.698kDa

Background of Gelsolin/GSN

Gelsolin, also known as GNS or brevin, is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. It is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. Gelsolin may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat, Monkey
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Immunocytochemistry/Immunofluorescence, 2μg/ml, Human
Flow Cytometry, 1-3μg/1x106 cells, Human

Validation Images & Assay Conditions

Gene/Protein Information For GSN (Source: Uniprot.org, NCBI)

Gene Name

GSN

Full Name

Gelsolin

Weight

85.698kDa

Superfamily

villin/gelsolin family

Alternative Names

Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; gelsolin (amyloidosis, Finnish type); Gelsolin; GSN GSN ADF, AGEL gelsolin gelsolin|actin-depolymerizing factor|brevin|epididymis secretory sperm binding protein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on GSN, check out the GSN Infographic

GSN infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for GSN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9209 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Cystatin C regulates the cytotoxicity of infection‐induced endothelial‐derived β‐amyloid

Balczon R, Morrow KA, Leavesley S, Francis CM, Stevens TC, Agwaramgbo E, Williams C, Stevens RP, Langham G, Voth S, Cioffi EA, Weintraub SE, Stevens T. Cystatin C regulates the cytotoxicity of infection-induced endothelial-derived β-amyloid. FEBS Open Bio
Species: Rat,P. aeruginosa
PB9209 usage in article: APP:WB, SAMPLE:PMVECS, DILUTION:NA

Guo, Y., Cui, L., Jiang, S., Zhang, A., & Jiang, S. (2017). Proteomics of acute heart failure in a rat post-myocardial infarction model. Molecular Medicine Reports, 16(2), 1946-1956. Advance online publication. doi: 10.3892/mmr.2017.6820

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Order DetailsPrice
PB9209

100μg

$370
PB9209-10ug

10μg sample (liquid)

$99
PB9209-Biotin

100 μg Biotin conjugated

$570
PB9209-Cy3

100 μg Cy3 conjugated

$570
PB9209-Dylight488

100 μg Dylight488 conjugated

$570
PB9209-Dylight550

100 μg Dylight550 conjugated

$570
PB9209-Dylight594

100 μg Dylight594 conjugated

$570
PB9209-FITC

100 μg FITC conjugated

$570
PB9209-HRP

100 μg HRP conjugated

$570
PB9209-APC

100 μg APC conjugated

$670
PB9209-PE

100 μg PE conjugated

$670
PB9209-carrier-free

Carrier Free

$370

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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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