Product Info Summary
SKU: | M00651 |
---|---|
Size: | 100 μl |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | Flow Cytometry, IP, IF, IHC, ICC, WB |
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Product info
Product Name
Anti-IL1RA Rabbit Monoclonal Antibody
View all IL-1ra/IL-1F3/IL1RN Antibodies
SKU/Catalog Number
M00651
Size
100 μl
Form
Liquid
Description
Boster Bio Anti-IL1RA Rabbit Monoclonal Antibody catalog # M00651. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-IL1RA Rabbit Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00651)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clonality
Monoclonal
Clone Number
GEI-9
Isotype
Rabbit IgG
Immunogen
A synthesized peptide derived from human IL1RA
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Detects ~20kDa. Does not cross-react with αB-crystallin, βL-crystallin, ΒH- crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.
Reactive Species
M00651 is reactive to IL1RN in Human, Mouse, Rat
Applications
M00651 is guaranteed for Flow Cytometry, IP, IF, IHC, ICC, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
20.055kDa
Background of IL-1ra/IL-1F3/IL1RN
Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Reconsitution
Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:5000-1:20000
IHC 1:50-1:200
ICC/IF 1:50-1:200
FC 1:50
IP 1:50
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of IL1RA expression in (1) HeLa cell lysate; (2) 3T3 cell lysate.
Protein Target Info & Infographic
Gene/Protein Information For IL1RN (Source: Uniprot.org, NCBI)
Gene Name
IL1RN
Full Name
Interleukin-1 receptor antagonist protein
Weight
20.055kDa
Alternative Names
DIRA; ICIL-1ra; IL1F3; IL-1F3; IL1ra; IL-1ra; IL-1ra3; IL1RN; IL-1RN; interleukin 1 receptor antagonist; IRAP; MVCD4 IL1RN DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4 interleukin 1 receptor antagonist interleukin-1 receptor antagonist protein|IL1 inhibitor|intracellular IL-1 receptor antagonist type II|intracellular interleukin-1 receptor antagonist (icIL-1ra)|type II interleukin-1 receptor antagonist
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IL1RN, check out the IL1RN Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IL1RN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IL1RA Rabbit Monoclonal Antibody (M00651)
Hello CJ!
M00651 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-? and IL-1? signaling
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Customer Reviews
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Customer Q&As
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3 Customer Q&As for Anti-IL1RA Rabbit Monoclonal Antibody
Question
Is this M00651 anti-IL1RA Rabbit Monoclonal antibody reactive to the isotypes of IL1RN?
Verified Customer
Verified customer
Asked: 2020-01-10
Answer
The immunogen of M00651 anti-IL1RA Rabbit Monoclonal antibody is A synthesized peptide derived from human IL1RA . Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?
Boster Scientific Support
Answered: 2020-01-10
Question
I was wanting to use your anti-IL1RA Rabbit Monoclonal antibody for WB for human lower esophagus mucosa on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for human lower esophagus mucosa identification?
Verified Customer
Verified customer
Asked: 2019-08-27
Answer
You can see on the product datasheet, M00651 anti-IL1RA Rabbit Monoclonal antibody has been tested for IP, IF, WB on human, mouse, rat tissues. We have an innovator award program that if you test this antibody and show it works in human lower esophagus mucosa in IHC-frozen, you can get your next antibody for free.
Boster Scientific Support
Answered: 2019-08-27
Question
Will anti-IL1RA Rabbit Monoclonal antibody M00651 work on pig IP with pancreas?
B. Taylor
Verified customer
Asked: 2017-10-16
Answer
Our lab technicians have not validated anti-IL1RA Rabbit Monoclonal antibody M00651 on pig. You can run a BLAST between pig and the immunogen sequence of anti-IL1RA Rabbit Monoclonal antibody M00651 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated pig samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in pig pancreas in IP, you can get your next antibody for free.
Boster Scientific Support
Answered: 2017-10-16