Rabbit IgG polyclonal antibody for C-X-C motif chemokine 10(CXCL10) detection. Tested with WB, IHC-P in Human. Cited in 1 publication(s).
Anti-IP10/CXCL10 Antibody Info At A Glance
|Product Name||Anti-IP10/CXCL10 Antibody
See all CXCL10/IP-10/CRG-2 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for IP 10/CXCL10 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. IP 10/CXCL10 information: Molecular Weight: 10881 MW; Subcellular Localization: Secreted.|
|Cite This Product||Anti-IP10/CXCL10 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1396)|
|Similar Products From
|Anti-IP10/CXCL10 Antibody may replace the following items: sc 101500|sc 1406|sc 14639|sc 160193|sc 160195|sc 28877|sc 367855|sc 58935.|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human IP10(79-98aa SKAIKNLLKAVSKERSKRSP).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For CXCL10 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||3627|
|Species Of This Entry||Human|
|Protein Name||C-X-C motif chemokine 10|
|Superfamily||intercrine alpha (chemokine CxC) family|
|Alternative Names||CXCL10/IP-10/CRG-2|C7; chemokine (C-X-C motif) ligand 10; CRG2; CRG-2; CXCL10; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10|
|Post Tranlational Modifications||Phosphorylation; Cleavage; Acetylation; Methylation; Citrullination; Deacetylation; Dephosphorylation; Ubiquitination; Glycosylation; Demethylation; Prenylation; Oxidation; Palmitoylation|
|Gene Location||4q21.1, on Chromasome 4, gene sequence: NC_000004.12 (76021118..76023497, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For CXCL10 (Source: Uniprot.org, NCBI)
|Protein Function||Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.|
|Interacting Proteins||CCL11; CCL13; CCL21; CCL26; CCL28; CCL5; CXCL12; CXCL9; DPP4; PF4|
|Related Diseases||Inflammation; Neoplasms; Virus Diseases; Malignant Neoplasms; Autoimmune Reaction; Infective Disorder; Nervousness; Tissue Adhesions; Inflammatory Response; Hepatitis; Sclerosis; Asthma; Tumor Angiogenesis; Multiple Sclerosis; Autoimmune Diseases; Diabetes Mellitus; Innate Immune Response; Cholangiocarcinoma; Fibrosis; Arthritis|
|Related Pathways||Pathogenesis; Immune Response; Secretion; Chemotaxis; Inflammatory Response; Chemokine Production; Angiogenesis; Cell Proliferation; Cell Migration; Cytokine Production; Innate Immune Response; Cell Death; Localization; Viral Replication; Chemokine Secretion; Cell Activation; Cell Adhesion; Hypersensitivity; Leukocyte Migration; Cell Growth|
|Background||C-X-C motif chemokine 10(CXCL10), also known as Interferon gamma-induced protein 10 kDa(IP-10) or small-inducible cytokine B10, is a protein that in humans is encoded by the CXCL10 gene. It is a small cytokine belonging to the CXC chemokine family. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. Luster et al.(1987) reported the isolation of an interferon-inducible gene that encodes a 98-amino acid protein called IP10. The chemokine IFN-gamma-inducible protein 10(IP-10; CXCL10), a CXC chemokine, and its receptor, CXCR3, were found to be overexpressed in lymph node cells of EAMG rats. IP10 inhibits bone marrow colony formation, has antitumor activity in vivo, is a chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells.|
|Scientific References||PMID: 3925348 by Luster A.D., et al. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins.|
PMID: 8423327 by Proost P., et al. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.
Our Boster Quality Guarantee for Anti-IP10/CXCL10 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Recombinant Human CXCL10 Protein 10ng
Lane 2: Recombinant Human CXCL10 Protein 5ng
Lane 3: Recombinant Human CXCL10 Protein 2.5ng
IHC(P): Human Mammary Cancer Tissue
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