Anti-IRAK-4 Antibody

IRAK4 antibody

Boster Bio Anti-IRAK-4 Antibody (Catalog # A01247-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

Product Info Summary

SKU: A01247-1
Size: 0.1 mg
Reactive Species: Human
Host: Rabbit
Application: ELISA, IF, ICC, WB

Product Name

Anti-IRAK-4 Antibody

View all IRAK4 Antibodies

SKU/Catalog Number

A01247-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-IRAK-4 Antibody (Catalog # A01247-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

Storage & Handling

IRAK-4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-IRAK-4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01247-1)

Host

Rabbit

Contents

IRAK-4 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Anti-IRAK4 antibody was raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human IRAK4. The immunogen is located within the last 50 amino acids of IRAK4.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

IRAK-4 antibody is predicted to not cross-react with other members of the IRAK protein family.

Reactive Species

A01247-1 is reactive to IRAK4 in Human

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

51530 MW

Background of IRAK4

Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-κB and MAP kinase (MAPK) by IL-1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4. Overexpression of IRAK-4 activates NF-κB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A01247-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1-4 μg/mL; ICC: 10 μg/mL; IF: 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For IRAK4 (Source: Uniprot.org, NCBI)

Gene Name

IRAK4

Full Name

Interleukin-1 receptor-associated kinase 4

Weight

51530 MW

Superfamily

protein kinase superfamily

Alternative Names

IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64 IRAK4 IMD67, IPD1, IRAK-4, NY-REN-64, REN64 interleukin 1 receptor associated kinase 4 interleukin-1 receptor-associated kinase 4|renal carcinoma NY-REN-64

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on IRAK4, check out the IRAK4 Infographic

IRAK4 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for IRAK4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A01247-1-0.1 mg

0.1 mg

$449

Free Secondary Antibody

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A01247-1
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$449.00

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