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- Table of Contents
Facts about Interleukin-1 receptor-associated kinase 4.
Phosphorylates originally IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino- mediated polyubiquitination of IRAK1.
Human | |
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Gene Name: | IRAK4 |
Uniprot: | Q9NWZ3 |
Entrez: | 51135 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; EC 2.7.11.1; interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; IRAK-4; NY-REN-64; REN64; Renal carcinoma antigen NY-REN-64
Mass (kDA):
51.53 kDA
Human | |
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Location: | 12q12 |
Sequence: | 12; NC_000012.12 (43758909..43789543) |
Cytoplasm.
PMID: 11960013 by Li S., et al. IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase.
PMID: 12496252 by Jiang Z., et al. Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.