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Product Info Summary
| SKU: | A02577 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Livin BIRC7 Antibody
SKU/Catalog Number
A02577
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Livin BIRC7 Antibody (Catalog # A02577). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Livin BIRC7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02577)
Host
Rabbit
Contents
Livin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Livin antibody was raised against a 17 amino acid peptide near the carboxy terminus of human Livin. The immunogen is located within the last 50 amino acids of Livin.
Cross-reactivity
A lower but much weaker band at 30 kDa was detected in Raji cell lysate, which may represent the short form of Livin.
Reactive Species
A02577 is reactive to BIRC7 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
32.8 kDa
Background of BIRC7
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-alpha and Livin-beta. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02577 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Recommend Dilution
Livin antibody can be used for detection of Livin by Western blot at 0.5 μg/mL. A band at 33 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Livin expression in human Raji cell lysate with Livin antibody at 0.5 μg/mL.
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Immunohistochemistry of Livin in human small intestine tissue with Livin antibody at 5 μg/mL.
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Immunofluorescence of Livin in Human Small Intestine cells with Livin antibody at 20 μg/mL.
Specific Publications For Anti-Livin BIRC7 Antibody (A02577)
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