Anti-LXR alpha/NR1H3 Antibody

NR1H3 antibody

Boster Bio Anti-LXR alpha/NR1H3 Antibody catalog # PA1246. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 1 publication(s).

Product Info Summary

SKU: PA1246
Size: 100μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

Product Name

Anti-LXR alpha/NR1H3 Antibody

View all NR1H3 Antibodies

SKU/Catalog Number

PA1246

Size

100μg/vial

Form

Lyophilized

Description

Boster Bio Anti-LXR alpha/NR1H3 Antibody catalog # PA1246. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-LXR alpha/NR1H3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1246)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human LXR alpha (375-398aa QVERLQHTYVEALHAYVSINHPHD), identical to the related rat and mouse sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross Reactivity

No cross reactivity with other proteins

Reactive Species

PA1246 is reactive to NR1H3 in Human, Mouse, Rat

Applications

PA1246 is guaranteed for WB Boster Guarantee

Background of NR1H3

LXRA is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity. It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit. Additionally, LXR activity is critical for physiologic lipid metabolism and transport. LXRs are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease. Furthermore, LXRs and their ligands are negative regulators of macrophage inflammatory gene expression. LXR is also found that as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis. The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Validation Images & Assay Conditions

Gene/Protein Information For NR1H3 (Source: Uniprot.Org, NCBI)

Uniprot ID

Q13133

Gene ID

10062

Gene Name

NR1H3

Full Name

Oxysterols receptor LXR-alpha

Weight

50.396kDa

Superfamily

nuclear hormone receptor family

Alternative Names

alpha; Liver X receptor alpha; liver X receptor-alpha; LXR alpha; LXRA; NR1H3; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD-1 NR1H3 LXR-a, LXRA, RLD-1 nuclear receptor subfamily 1 group H member 3 oxysterols receptor LXR-alpha|liver X nuclear receptor alpha variant 1

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on NR1H3, check out the NR1H3 Infographic

NR1H3 infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for NR1H3: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

PA1246 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Shang W, Yu X, Wang H, Chen T, Fang Y, Yang X, Zhou P, Nie F, Zhou Q, Zhou J. Mol Med Rep. 2015 Jan;11(1):503-8. Doi: 10.3892/Mmr.2014.2731. Epub 2014 Oct 21. Fibroblast Growth Factor 21 Enhances Cholesterol Efflux In Thp-1 Macrophage-Derived Foam...

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SKU:PA1246

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PA1246
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$315.00

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