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Product Info Summary
|Reactive Species:||Human, Mouse, Rat|
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Anti-LXR alpha/NR1H3 Antibody
Boster Bio Anti-LXR alpha/NR1H3 Antibody catalog # PA1246-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-LXR alpha/NR1H3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1246-1)
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
A synthetic peptide corresponding to a sequence at the C-terminus of human LXR alpha (371-385aa NVQDQLQVERLQHTY), identical to the related rat and mouse sequences.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
No cross-reactivity with other proteins
PA1246-1 is reactive to NR1H3 in Human, Mouse, Rat
PA1246-1 is guaranteed for WB Boster Guarantee
Background of NR1H3
LXRA is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity. It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit. Additionally, LXR activity is critical for physiologic lipid metabolism and transport. LXRs are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease. Furthermore, LXRs and their ligands are negative regulators of macrophage inflammatory gene expression. LXR is also found that as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis. The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake.
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
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Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Validation Images & Assay Conditions
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Anti-NR1H3 antibody, PA1246-1, Western blotting
All lanes: Anti NR1H3 (PA1246-1) at 0.5ug/ml
Lane 1: Rat Liver Tissue Lysate at 50ug
Lane 2: Rat Lung Tissue Lysate at 50ug
Lane 3: Rat Spleen Tissue Lysate at 50ug
Lane 4: Rat Kidney Tissue Lysate at 50ug
Lane 5: Human Placenta Tissue Lysate at 50ug
Predicted bind size: 51KD
Observed bind size: 51KD
Gene/Protein Information For NR1H3 (Source: Uniprot.org, NCBI)
Oxysterols receptor LXR-alpha
nuclear hormone receptor family
alpha; Liver X receptor alpha; liver X receptor-alpha; LXR alpha; LXRA; NR1H3; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD-1 NR1H3 LXR-a, LXRA, RLD-1 nuclear receptor subfamily 1 group H member 3 oxysterols receptor LXR-alpha|liver X nuclear receptor alpha variant 1*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".
For more info on NR1H3, check out the NR1H3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NR1H3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]
PA1246-1 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Shang W, Yu X, Wang H, Chen T, Fang Y, Yang X, Zhou P, Nie F, Zhou Q, Zhou J. Mol Med Rep. 2015 Jan;11(1):503-8. Doi: 10.3892/Mmr.2014.2731. Epub 2014 Oct 21. Fibroblast Growth Factor 21 Enhances Cholesterol Efflux In Thp-1 Macrophage-Derived Foam...
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