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- Table of Contents
NR1H3 Antibodies
AND NR1H3 ELISA kits, NR1H3 Proteins
Many biological assays use antibodies to detect NR1H3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR1H3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR1H3 antibodies...
Designing a Western blot for NR1H3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NR1H3 Western Blot GuideDesigning an IHC experiment for NR1H3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NR1H3 IHC GuideNR1H3 Infographic by Boster Bio
All NR1H3 Products
Product
Figures
Specificity
Applications
Price
Anti-NR1H3 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03331-3
100 µg/vial
Cat # A03331-3
100 µg/vial
Anti-LXR alpha/NR1H3 Antibody Picoband®
1 Citations
Human, Mouse, Rat
WB
$370
Cat # PA1246-1
100 μg/vial
Cat # PA1246-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M03331
100 μl
Cat # M03331
100 μl
NR1H3 Overview
Facts about Oxysterols receptor LXR-alpha.
Oxysterols receptor LXR-alpha (NR1H3)
Nuclear receptor that shows a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding spouse to an active ligand-binding subunit in mediating retinoid responses through target genes characterized by LXRES (By similarity).
LXRES are DR4-type response components characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake via MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530).
Gene Information
| Human | |
|---|---|
| Gene Name: | NR1H3 |
| Uniprot: | Q13133 |
| Entrez: | 10062 |
Family
| Belongs to: |
|---|
| nuclear hormone receptor family |
Alternative Names
alpha; Liver X receptor alpha; liver X receptor-alpha; LXR alpha; LXRA; NR1H3; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD-1
Molecular Weight
Mass (kDA):
50.396 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (47248300..47269033) |
Tissue Specificity
Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Diabetes Mellitus
- Cardiovascular Diseases
- Inflammation
- Malignant Neoplasms
- Hypercholesterolemia
- Steatosis
- Diabetes Mellitus, Non-insulin-dependent
- Atherosclerosis
- Dyslipidemias
- Pre-eclampsia
- Cell Invasion
- Insulin Sensitivity
- Obesity
Interacting Proteins
- EDF1
- KDM1A
- MDFI
- NCOA1
- NCOR1
- PPARA
- PPARD
- PPARG
- RXRA
- RXRB
Pathways
- Cholesterol Homeostasis
- Transport
- Cholesterol Efflux
- Cholesterol Transport
- Reverse Cholesterol Transport
- Lipid Homeostasis
- Secretion
- Aging
- Excretion
- Response To Lipid
- Gluconeogenesis
- Keratinocyte Differentiation
- Cell Cycle Arrest
PTMs
- Phosphorylation
Research Areas
- Cancer
- Cholesterol Metabolism
- Chromatin Research
- Diabetes Research
- Lipid and Metabolism
- Signal Transduction
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR1H3
bosterbio.com/bosterbio-gene-info-cards/NR1H3
References
PMID: 7744246 by Willy P.J., et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway.
PMID: 19481530 by Jakobsson T., et al. GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.
1 Publications of Boster NR1H3 Antibodies & ELISA Kits
- PubMed ID: 25334019, Shang W, Yu X, Wang H, Chen T, Fang Y, Yang X, Zhou P, Nie F, Zhou Q, Zhou J. Mo...
*More publications can be found for each product on its corresponding product page