Oxysterols receptor LXR-alpha (NR1H3)

Nuclear receptor that shows a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding spouse to an active ligand-binding subunit in mediating retinoid responses through target genes characterized by LXRES (By similarity).

LXRES are DR4-type response components characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake via MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530).