Introduction
DCK (Deoxycytidine kinase) is a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues. DCK is responsible for the 5`-phosphorylation of purine and pyrimidine deoxynucleosides to the corresponding monophosphates using ATP or UTP as phosphate donors. Deficiency of the DCK enzyme activity is linked to resistance to antiviral and anticancer chemotherapeutic agents, whereas increased DCK enzyme activity is linked to increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.
Overview
| Product Name |
Anti-Mcm7 Antibody (Monoclonal, DCS-141)
|
| SKU/Catalog Number |
MA1058 |
| Pack Size |
100μg/vial |
| Storage & Handling |
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing. |
| Description |
Monoclonal clone# G2 antibody for MCM7 detection. Host: Mouse.Size: 100μg/vial. Tested applications: ICC. Reactive species: Human. MCM7 information: Molecular Weight: 81063 MW; Subcellular Localization: Nucleus . |
| Cite This Product |
Anti-Mcm7 Antibody (Monoclonal, DCS-141) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1058)
|
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Anti-Mcm7 Antibody (Monoclonal, DCS-141) may replace the following items: sc 9794|sc 56429|sc 9847|sc 374403|sc 22782|sc 65469|sc 65475|sc 56324|sc 71550|sc 46687|sc 9966|sc 6688. |
Product Specs
| Host |
Mouse |
| Reactivity/Species |
Human |
| Applications |
ICC, WB
*Our Boster Guarantee covers the use of this product in the above
tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products. |
| Related Products |
Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for ICC.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round. |
| Immunogen |
Recombinant human Mcm7. |
| Cross Reactivity |
No cross reactivity with other proteins |
Gene/Protein Basic Information For MCM7 (Source: Uniprot.org, NCBI)
| Uniprot Id | Q6AYN8 |
|---|
| Gene Name | MCM7 |
|---|
| Molecular Weight | 81063 MW |
|---|
| Subcellular Localization | Nucleus . |
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*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For MCM7 (Source: Uniprot.org, NCBI)
| Protein Function | MCM7: Acts as component of the MCM2-7 complex (MCM complex)which is the putative replicative helicase essential for 'once percell cycle' DNA replication initiation and elongation ineukaryotic cells. The active ATPase sites in the MCM2-7 ring areformed through the interaction surfaces of two neighboringsubunits such that a critical structure of a conserved argininefinger motif is provided in trans relative to the ATP-binding siteof the Walker A box of the adjacent subunit. The six ATPase activesites, however, are likely to contribute differentially to thecomplex helicase activity. Required for S-phase checkpointactivation upon UV-induced damage. |
|---|
| Background | Initiation of DNA replication is a complex process involving the concerted action of many proteins. The chromosome 7-linked gene referred to by Nakatsuru et al. as MCM2 has been designated MCM7. The MCM2-7 complex is comprised of 6 subunits, MCM2 through MCM7, and is a ring-shaped heterohexameric ATPase involved in DNA replication. MCM7 is located in 7q21.3-q22.1. |
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Our Boster Quality Guarantee for Anti-Mcm7 Antibody (Monoclonal, DCS-141) covers its use in the following applications.
Immunocytochemistry , 1μg/ml, Human, -
Western blot, 0.5-1μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Specific Protocols
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
See all primary antibodies,
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