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Product Info Summary
|Application:||IHC, ICC, WB|
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Anti-P-GlycoProtein(MDR) ABCB4 Antibody (Monoclonal, F4)
Boster Bio Anti-P-GlycoProtein (MDR) ABCB4 Antibody (Monoclonal, F4) catalog # MA1060. Tested in IHC, ICC, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-P-GlycoProtein(MDR) ABCB4 Antibody (Monoclonal, F4) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1060)
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Mixture of human and hamster drug-resistant whole cells and crude plasma membranes.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
No cross reactivity with other proteins
MA1060 is reactive to ABCB4 in Human
MA1060 is guaranteed for IHC, ICC, WB Boster Guarantee
Background of Abcb1a
P-Glycoprotein,, also known as Multidrug Resistance 1 (MDR1), is one of the ATP-binding cassette transporters family. P-glycoprotein-1 is involved in the transport of 3 of these protease inhibitors in vitro. MDR1 gene is mapped to the 7q21.1 by in situ hybridization. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
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Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 1-2μg/ml, Human, By Heat
Immunocytochemistry , 1μg/ml, Human, -
Immunohistochemistry (Frozen Section), 1-2μg/ml, Human, -
Western blot, 0.5-1μg/ml, Human
Validation Images & Assay Conditions
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Boster Kit Box
Gene/Protein Information For ABCB4 (Source: Uniprot.org, NCBI)
ATP-dependent translocase ABCB1
ABC transporter superfamily
ATP-dependent translocase ABCB1 Abcb1a|Abcb4, Evi, Evi32, Mdr, Mdr1a, Mdr3, P, P-, P-gp, Pgp, Pgy, Pgy-, Pgy-3, Pgy3, mdr-, mdr-3|ATP-binding cassette, sub-family B (MDR/TAP), member 1A|ATP-dependent translocase ABCB1|ATP-binding cassette sub-family B member 1A|ATP-binding cassette, sub-family B (MDR/TAP), member 4|ATP-binding cassette, subfamily B, member 1A|P-glycoprotein 3|ecotropic viral integration site 32|multi-drug resistance 3|multidrug resistance protein 3|multiple drug resistant 1a|phospholipid transporter ABCB1*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".
For more info on ABCB4, check out the ABCB4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ABCB4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]
MA1060 has been cited in 3 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Chemoresistance in Malignant Intracranial Tumors: Longer Survival with Negative MDR1 Expression.
Gao S, Liu Q, Wang X, Lin B, Zhang S. Med Oncol. 2010 Sep;27(3):960-7. Doi: 10.1007/S12032-009-9317-6. Epub 2009 Sep 23. Effects Of Lewis Y Antigen On The Gene Expression Of Multiple Drug Resistance-Associated Proteins In Human Ovarian Cancer Rmg-...
Wang X, Deng R, Lu Y, Xu Q, Yan M, Ye D, Chen W. Basic Clin Pharmacol Toxicol. 2013 Jan;112(1):25-33. Doi: 10.1111/J.1742-7843.2012.00921.X. Epub 2012 Aug 22. Gambogic Acid As A Non-Competitive Inhibitor Of Atp-Binding Cassette Transporter B1 Reve...
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