Anti-p57 CDKN1C Antibody

p57 Kip2 antibody

Boster Bio Anti-p57 CDKN1C Antibody catalog # A01244. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A01244
Size: 100μl
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-p57 CDKN1C Antibody

View all p57 Kip2 Antibodies

SKU/Catalog Number

A01244

Size

100μl

Form

Liquid

Description

Boster Bio Anti-p57 CDKN1C Antibody catalog # A01244. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-p57 CDKN1C Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01244)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

8B3A11

Isotype

IgG

Immunogen

Synthesized peptide derived from human p57 around the non-acetylation site of K278.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A01244 is reactive to CDKN1C in Human, Mouse, Rat

Applications

A01244 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

32.177kDa

Background of p57 Kip2

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Doppler H, et al. (2005) J Biol Chem. 280(15):15013-15019.
McKinsey TA, et al. (2000) Nature. 408(6808): 106-111.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Innovating Scientists Reward

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000
IHC-P, 1:100-1:300

Validation Images & Assay Conditions

Gene/Protein Information For CDKN1C (Source: Uniprot.org, NCBI)

Gene Name

CDKN1C

Full Name

Cyclin-dependent kinase inhibitor 1C

Weight

32.177kDa

Superfamily

CDI family

Alternative Names

Beckwith-Wiedemann syndrome; BWS; cyclin-dependent kinase inhibitor 1C (p57, Kip2); cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP2BWCR; p57; p57Kip2; WBS CDKN1C BWCR, BWS, KIP2, WBS, p57, p57Kip2 cyclin dependent kinase inhibitor 1C cyclin-dependent kinase inhibitor 1C|cyclin-dependent kinase inhibitor 1C (p57, Kip2)|cyclin-dependent kinase inhibitor p57

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CDKN1C, check out the CDKN1C Infographic

CDKN1C infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CDKN1C: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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6 Customer Q&As for Anti-p57 CDKN1C Antibody

Question

Is there a BSA free version of anti-p57 antibody A01244 available?

Verified Customer

Verified customer

Asked: 2019-11-29

Answer

Thanks for your recent telephone inquiry. I can confirm that some lots of this anti-p57 antibody A01244 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.

Boster Scientific Support

Answered: 2019-11-29

Question

Is this A01244 anti-p57 antibody reactive to the isotypes of CDKN1C?

G. Jha

Verified customer

Asked: 2019-11-04

Answer

The immunogen of A01244 anti-p57 antibody is Synthesized peptide derived from human p57 around the non-acetylation site of K278. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2019-11-04

Question

Will anti-p57 antibody A01244 work on pig WB with embryo?

Verified Customer

Verified customer

Asked: 2018-10-19

Answer

Our lab technicians have not tested anti-p57 antibody A01244 on pig. You can run a BLAST between pig and the immunogen sequence of anti-p57 antibody A01244 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated pig samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in pig embryo in WB, you can get your next antibody for free.

Boster Scientific Support

Answered: 2018-10-19

Question

I was wanting to use your anti-p57 antibody for WB for mouse metanephric glomerulus on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for mouse metanephric glomerulus identification?

Verified Customer

Verified customer

Asked: 2018-06-22

Answer

It shows on the product datasheet, A01244 anti-p57 antibody has been validated for IHC, WB on human, mouse, rat tissues. We have an innovator award program that if you test this antibody and show it works in mouse metanephric glomerulus in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2018-06-22

Question

Is a blocking peptide available for product anti-p57 antibody (A01244)?

W. Zhao

Verified customer

Asked: 2016-05-30

Answer

We do provide the blocking peptide for product anti-p57 antibody (A01244). If you would like to place an order for it please contact [email protected] and make a special request.

Boster Scientific Support

Answered: 2016-05-30

Question

We appreciate helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for metanephric glomerulus using anti-p57 antibody A01244. Let me know if you need anything else.

M. Walker

Verified customer

Asked: 2014-11-24

Answer

Thank you for the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2014-11-24

Order DetailsPrice
A01244

100uL

$399

Free Secondary Antibody

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A01244
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$399.00

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