CDKN1C Antibodies

Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation.

May play a role in maintenance of the non- proliferative state throughout life. .

Gene Information

Human
Gene Name:	CDKN1C
Uniprot:	P49918
Entrez:	1028

Family

Belongs to:
CDI family

Alternative Names

Beckwith-Wiedemann syndrome; BWS; cyclin-dependent kinase inhibitor 1C (p57, Kip2); cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP2BWCR; p57; p57Kip2; WBS

Molecular Weight

Mass (kDA):
32.177 kDA

Genomic Context

Human
Location:	11p15.4
Sequence:	11; NC_000011.10 (2883218..2885775, complement)

Tissue Specificity

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

Subcellular Localizations

Nucleus.

Diseases

• Neoplasms
• Malignant Neoplasms
• Beckwith-wiedemann Syndrome
• Carcinoma
• Cell Transformation, Neoplastic
• Hyperplasia
• Hydatidiform Mole
• Nephroblastoma
• Uterine Neoplasms
• Complete Hydatidiform Mole
• Partial Hydatidiform Mole
• Malignant Paraganglionic Neoplasm

• Neoplasm Metastasis
• Uniparental Disomy
• Leukemia
• Cell Invasion
• Triploidy
• Retinoblastoma
• Kidney Neoplasm

Interacting Proteins

• FBXL12
• MCM7

Pathways

• Cell Cycle
• Methylation
• Cell Proliferation
• Dna Methylation
• Cell Cycle Arrest
• Pathogenesis
• Cell Differentiation
• Cell Growth
• Senescence
• Cell Death
• Localization
• S Phase
• Gene Silencing

• G1 Phase
• Cell Division
• Regulation Of Cell Proliferation
• Ossification
• Regeneration
• Transport
• Histone Deacetylation

PTMs

• Methylation
• Phosphorylation
• Acetylation
• Reduction
• Cleavage

• Deacetylation
• Demethylation
• Sumoylation
• Glutathionylation
• Dephosphorylation

• Ubiquitination

Research Areas

• Breast Cancer
• Cancer
• Cell Cycle and Replication
• Core ESC-Like Genes
• DNA Repair

• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDKN1C

Best Uses Of The CDKN1C Marker

This article will provide details about the CDKN1C and Boster's high affinity primary antibodies. If you're unfamiliar with Boster is an American geneticist who has been conducting studies on the human genome for more than 20 years. His research has been recognized with many awards and are seen as being among the most influential in genetic research. Boster's work has impacted numerous aspects of human health as well as the development of life-saving drugs and medical devices.

Steven Boster

Dr. Steven Boster passed away at Buffalo Equine in Madison, WI on February 3 2019. Born in Joliet, IL, he was fighting COVID-19 for last three years. He is the father of Donald, Sr. and David Boster. His mother Frances, and sister Kimberly, are his survivors. Jonathan, his son Jonathan and grandson Cory, IL, are also survivors.

Steven Boster's high affinity primary antibodies

High-affinity primary antibodies (also known as the antigen of interest) are immunoglobulins which recognize a specific antigen. The quality of the primary antibodies is typically determined by their specificity and affinity with a greater affinity that indicates a higher antibody's ability to recognize a target antigen. Good primary antibodies can also be utilized to detect, quantify, and purify the antigen of your interest.