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- Table of Contents
PAK3 Antibodies
AND PAK3 ELISA kits, PAK3 Proteins
Many biological assays use antibodies to detect PAK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAK3 antibodies...
Designing a Western blot for PAK3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PAK3 Western Blot GuideDesigning an IHC experiment for PAK3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PAK3 IHC GuidePAK3 Infographic by Boster Bio
All PAK3 Products
Product
Figures
Specificity
Applications
Price
Anti-PAK3 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03124-1
100 μg/vial
Cat # A03124-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # P03124
100 μl
Cat # P03124
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2577
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2577
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1438
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1438
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2103
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2103
1 kit, containing two 96-well plates and all necessary reagents
PAK3 Overview
Facts about Serine/threonine-protein kinase PAK 3.
Serine/threonine-protein kinase PAK 3 (PAK3)
Serine/threonine protein kinase that plays a role in many different different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity.
Activation by the binding of active CDC42 and RAC1 leads to a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAK3 |
| Uniprot: | O75914 |
| Entrez: | 5063 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
beta-PAK; bPAK; CDKN1A; EC 2.7.11; EC 2.7.11.1; hPAK3; mental retardation, X-linked 47; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; PAK3; PAK-3; PAK3beta; serine/threonine-protein kinase PAK 3
Molecular Weight
Mass (kDA):
62.31 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq23 |
| Sequence: | X; NC_000023.11 (110944241..111227361) |
Tissue Specificity
Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
Subcellular Localizations
Cytoplasm.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Nervousness
- Mental Disorders
- Neuroblastoma
- Cognition Disorders
- Microcephaly
- Epilepsy
- Immunologic Deficiency Syndromes
- Lissencephaly
Interacting Proteins
- RAC1
Pathways
- Cell Cycle
- Cell Migration
- Cell Adhesion
- Cognition
- Cell Proliferation
- Synaptic Transmission
- Endocytosis
- Methylation
- Cell Death
- Cell Division
- Jnk Cascade
- Pathogenesis
- Transport
PTMs
- Phosphorylation
- Cleavage
- Methylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAK3
bosterbio.com/bosterbio-gene-info-cards/PAK3
References
PMID: 9731525 by Allen K.M., et al. PAK3 mutation in nonsyndromic X-linked mental retardation.
PMID: 12777533 by Kitano T., et al. Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.