Anti-PAPP-A Antibody (Monoclonal, ABM4C62)

Pappalysin-1/PAPP-A antibody

Boster Bio Anti-PAPP-A Antibody (Monoclonal, ABM4C62) (Catalog# M06838). Tested in IHC application(s). This antibody reacts with Human.

Product Info Summary

SKU: M06838
Size: 100 µg
Reactive Species: Human
Host: Mouse
Application: IHC

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Product Name

Anti-PAPP-A Antibody (Monoclonal, ABM4C62)

View all Pappalysin-1/PAPP-A Antibodies

SKU/Catalog Number

M06838

Size

100 µg

Form

Liquid

Description

Boster Bio Anti-PAPP-A Antibody (Monoclonal, ABM4C62) (Catalog# M06838). Tested in IHC application(s). This antibody reacts with Human.

Storage & Handling

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Cite This Product

Anti-PAPP-A Antibody (Monoclonal, ABM4C62) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M06838)

Host

Mouse

Contents

100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide.

Clonality

Monoclonal

Clone Number

ABM4C62

Isotype

IgG2b Kappa

Immunogen

A partial length recombinant PAPP-A protein (amino acids 332-561)

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Does not cross-react with primate, avian or amphibian GR.

Reactive Species

M06838 is reactive to PAPPA in Human

Reconstitution

Reconstitute with distilled water.

Observed Molecular Weight

68 kDa

Calculated molecular weight

192708 MW

Background of Pappalysin-1/PAPP-A

Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M06838 is guaranteed for IHC Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC: 5-10 µg/ml

Validation Images & Assay Conditions

Gene/Protein Information For PAPPA (Source: Uniprot.org, NCBI)

Gene Name

PAPPA

Full Name

Pappalysin-1

Weight

192708 MW

Superfamily

peptidase M43B family

Alternative Names

Papp-a2;Pappalysin 2;pappa2;papp-a2; PAPPA ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A1, PAPPA pappalysin 1 pappalysin-1|IGF-dependent IGFBP-4 protease|aspecific BCL2 ARE-binding protein 2|differentially placenta 1 expressed protein|insulin-like growth factor-dependent IGF binding protein-4 protease|pregnancy-associated plasma protein A, pappalysin 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on PAPPA, check out the PAPPA Infographic

PAPPA infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PAPPA: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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1 Customer Q&As for Anti-PAPP-A Antibody (Monoclonal, ABM4C62)

Question

We are currently using anti-PAPP-A antibody (Monoclonal, ABM4C62) M06838 for human tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on zebrafish tissues as well?

Verified Customer

Verified customer

Asked: 2019-12-18

Answer

The anti-PAPP-A antibody (Monoclonal, ABM4C62) (M06838) has not been tested for cross reactivity specifically with zebrafish tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-12-18

Order DetailsPrice
M06838-100ug

100 μg

$366

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M06838
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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