Product Info Summary
SKU: | M06838 |
---|---|
Size: | 100 µg |
Reactive Species: | Human |
Host: | Mouse |
Application: | IHC |
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Product info
Product Name
Anti-PAPP-A Antibody (Monoclonal, ABM4C62)
View all Pappalysin-1/PAPP-A Antibodies
SKU/Catalog Number
M06838
Size
100 µg
Form
Liquid
Description
Boster Bio Anti-PAPP-A Antibody (Monoclonal, ABM4C62) (Catalog# M06838). Tested in IHC application(s). This antibody reacts with Human.
Storage & Handling
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Cite This Product
Anti-PAPP-A Antibody (Monoclonal, ABM4C62) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M06838)
Host
Mouse
Contents
100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide.
Clonality
Monoclonal
Clone Number
ABM4C62
Isotype
IgG2b Kappa
Immunogen
A partial length recombinant PAPP-A protein (amino acids 332-561)
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Does not cross-react with primate, avian or amphibian GR.
Reactive Species
M06838 is reactive to PAPPA in Human
Reconstitution
Reconstitute with distilled water.
Observed Molecular Weight
68 kDa
Calculated molecular weight
192708 MW
Background of Pappalysin-1/PAPP-A
Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M06838 is guaranteed for IHC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 5-10 µg/ml
Validation Images & Assay Conditions
Click image to see more details
Immunohistochemical analysis of PAPP-A in human Placenta tissue using PAPP-A antibody (Clone: ABM4C62) at 5 &mu
Protein Target Info & Infographic
Gene/Protein Information For PAPPA (Source: Uniprot.org, NCBI)
Gene Name
PAPPA
Full Name
Pappalysin-1
Weight
192708 MW
Superfamily
peptidase M43B family
Alternative Names
Papp-a2;Pappalysin 2;pappa2;papp-a2; PAPPA ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A1, PAPPA pappalysin 1 pappalysin-1|IGF-dependent IGFBP-4 protease|aspecific BCL2 ARE-binding protein 2|differentially placenta 1 expressed protein|insulin-like growth factor-dependent IGF binding protein-4 protease|pregnancy-associated plasma protein A, pappalysin 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PAPPA, check out the PAPPA Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PAPPA: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PAPP-A Antibody (Monoclonal, ABM4C62) (M06838)
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No publications found for M06838
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Customer Q&As
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1 Customer Q&As for Anti-PAPP-A Antibody (Monoclonal, ABM4C62)
Question
We are currently using anti-PAPP-A antibody (Monoclonal, ABM4C62) M06838 for human tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on zebrafish tissues as well?
Verified Customer
Verified customer
Asked: 2019-12-18
Answer
The anti-PAPP-A antibody (Monoclonal, ABM4C62) (M06838) has not been tested for cross reactivity specifically with zebrafish tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-12-18