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- Table of Contents
Pappalysin-1 Antibodies
AND PAPPA ELISA kits, Pappalysin-1 Proteins
Many biological assays use antibodies to detect Pappalysin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pappalysin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pappalysin-1 antibodies...
Designing a Western blot for Pappalysin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PAPPA Western Blot GuideDesigning an IHC experiment for Pappalysin-1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PAPPA IHC GuidePAPPA Infographic by Boster Bio
All PAPPA Products
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Specificity
Applications
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PAPPA Overview
Facts about Pappalysin-1.
Pappalysin-1 (PAPPA)
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
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Gene Information
| Human | |
|---|---|
| Gene Name: | PAPPA |
| Uniprot: | Q13219 |
| Entrez: | 5069 |
Family
| Belongs to: |
|---|
| peptidase M43B family |
Alternative Names
ASBABP2; DIPLA1; EC 3.4.24.79; IGFBP-4ase; IGFBP-4aseaspecific BCL2 ARE-binding protein 2; IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF binding protein-4 protease; Insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPA; PAPPA; PAPPA1; PAPP-A1; PAPP-Adifferentially placenta 1 expressed protein; Pappalysin1; Pappalysin-1; pregnacy-associated plasma protein A; Pregnancy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1
Molecular Weight
Mass (kDA):
180.973 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q33.1 |
| Sequence: | 9; NC_000009.12 (116153752..116402321) |
Tissue Specificity
High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
Subcellular Localizations
Secreted.
Diseases
- Malignant Neoplasms
- Pre-eclampsia
- Neoplasms
- Pregnancy Complications
- Down Syndrome
- Hypertension Induced By Pregnancy
- Ovarian Neoplasm
- Malignant Neoplasm Of Ovary
- Cell Invasion
- Hypertensive Disease
- Cholangiocarcinoma
- Neoplasm Metastasis
Pathways
- Proteolysis
- Aging
- Cell Adhesion
- Cell Activation
- T Cell Activation
- Protein Secretion
- Ossification
- System Process
- Cytoskeleton Organization
- Tissue Development
- Translation
- Cell Differentiation
- Bone Development
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAPPA
bosterbio.com/bosterbio-gene-info-cards/PAPPA
References
PMID: 8620868 by Haaning J., et al. Complete cDNA sequence of the preproform of human pregnancy- associated plasma protein-A. Evidence for expression in the brain and induction by cAMP.
PMID: 7508748 by Kristensen T., et al. Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA.