Product Info Summary
SKU: | A00350Y1141 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, WB |
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Product info
Product Name
Anti-Phospho-Ob-R (Y1141) LEPR Antibody
SKU/Catalog Number
A00350Y1141
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Phospho-Ob-R (Y1141) LEPR Antibody catalog # A00350Y1141. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Phospho-Ob-R (Y1141) LEPR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00350Y1141)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Ob-R around the phosphorylation site of Y1141.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00350Y1141 is reactive to LEPR in Human, Mouse
Applications
A00350Y1141 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
132.494kDa
Background of Leptin R
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Dolganov G.M., Mol. Cell. Biol. 16:4832-4841(1996).
Kim K.K., Gene 235:59-67(1999).
Carney J.P., Cell 93:477-486(1998).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
ELISA 1:5000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-Phospho-Ob-R (Y1141) LEPR Antibody A00350Y1141
Western Blot (WB) analysis of extracts from K562 cellsProtein Target Info & Infographic
Gene/Protein Information For LEPR (Source: Uniprot.org, NCBI)
Gene Name
LEPR
Full Name
Leptin receptor
Weight
132.494kDa
Superfamily
type I cytokine receptor family
Alternative Names
B219; CD295 antigen; CD295; DB; DKFZp686B1731; huB219; LEPR; LEP-R; Leptin R; leptin receptor; LeptinR; OB R; OB receptor; OB-R; OBRCD295 LEPR CD295, LEP-RD, OB-R, OBR, LEPR leptin receptor leptin receptor|OB receptor|huB219
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LEPR, check out the LEPR Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LEPR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospho-Ob-R (Y1141) LEPR Antibody (A00350Y1141)
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No publications found for A00350Y1141
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