Anti-Phospho-Tuberin (Y1571) TSC2 Antibody

TSC2 antibody

Boster Bio Anti-Phospho-Tuberin (Y1571) TSC2 Antibody catalog # A00229Y1571. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A00229Y1571
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, IHC, WB

Product Name

Anti-Phospho-Tuberin (Y1571) TSC2 Antibody

View all TSC2 Antibodies

SKU/Catalog Number

A00229Y1571

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Phospho-Tuberin (Y1571) TSC2 Antibody catalog # A00229Y1571. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Phospho-Tuberin (Y1571) TSC2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00229Y1571)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human Tuberin around the phosphorylation site of Y1571.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A00229Y1571 is reactive to TSC2 in Human, Mouse, Rat

Applications

A00229Y1571 is guaranteed for ELISA, IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

200.608kDa

Background of TSC2

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.

Opipari A.W. Jr., J. Biol. Chem. 265:14705-14708(1990).
Mungall A.J., Nature 425:805-811(2003).
Eliopoulos A.G., J. Virol. 73:1023-1035(1999).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000

Validation Images & Assay Conditions

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Gene/Protein Information For TSC2 (Source: Uniprot.org, NCBI)

Gene Name

TSC2

Full Name

Tuberin

Weight

200.608kDa

Alternative Names

LAM; LAMFLJ43106; TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein; tuberous sclerosis 2 TSC2 LAM, PPP1R160, TSC4 TSC complex subunit 2 tuberin|protein phosphatase 1, regulatory subunit 160|tuberous sclerosis 2 protein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on TSC2, check out the TSC2 Infographic

TSC2 infographic

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In this infographic, you will see the following information for TSC2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A00229Y1571-100ul

100ul

$380

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