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- Table of Contents
Tuberin Antibodies
AND TSC2 ELISA kits, Tuberin Proteins
Many biological assays use antibodies to detect Tuberin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tuberin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tuberin antibodies...
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TSC2 Infographic by Boster Bio
All TSC2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9121
100 μg/vial
Cat # PB9121
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M00229
100 μl
Cat # M00229
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1579
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1579
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2131
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2131
1 kit, containing two 96-well plates and all necessary reagents
Human
Flow Cytometry, IHC, WB
$370
Cat # M00229-1
100 μg/vial
Cat # M00229-1
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00229S939-1
100ul
Cat # A00229S939-1
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00229T1462-2
100ul
Cat # A00229T1462-2
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00229Y1571
100ul
Cat # A00229Y1571
100ul
Human, Mouse
IHC, WB
$370
Cat # M00229T1462
100 µl/vial
Cat # M00229T1462
100 µl/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # M00229S939
100 µl/vial
Cat # M00229S939
100 µl/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P00229
100 μl/vial
Cat # P00229
100 μl/vial
TSC2 Overview
Facts about Tuberin.
Tuberin (TSC2)
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059).
May also play a part in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TSC2 |
| Uniprot: | P49815 |
| Entrez: | 7249 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
LAM; LAMFLJ43106; TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein; tuberous sclerosis 2
Molecular Weight
Mass (kDA):
200.608 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (2047804..2089491) |
Tissue Specificity
Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.
Diseases
- Tuberous Sclerosis
- Sclerosis
- Neoplasms
- Malignant Neoplasms
- Hamartoma
- Kidney Neoplasm
- Angiomyolipoma
- Epilepsy
- Carcinoma
- Lymphangioleiomyomatosis
- Hereditary Diseases
- Renal Cell Carcinoma
Interacting Proteins
- PPP1CA
- SGK1
- SIRT1
- TSC1
- YWHAB
- YWHAZ
Pathways
- Cell Growth
- Pathogenesis
- Translation
- Cell Cycle
- Cell Proliferation
- Localization
- Autophagy
- Cell Death
- Brain Development
- Angiogenesis
- Dna Repair
- Cell Migration
- Cell Differentiation
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Ubiquitination
- Farnesylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSC2
bosterbio.com/bosterbio-gene-info-cards/TSC2
References
PMID: 8269512 by Nellist M., et al. Identification and characterization of the tuberous sclerosis gene on chromosome 16.
PMID: 7558029 by Xu L., et al. Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues.